ArticleThe American journal of pathology2002
Thymosin-beta4 regulates motility and metastasis of malignant mouse fibrosarcoma cells.
Article in The American journal of pathology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
45 citing papers in PubMed, 123 citations in OpenAlex.
- Thymosin βCells · 2024Review
- Cytoskeletal and Cytoskeleton-Associated Proteins: Key Regulators of Cancer Stem Cell Properties.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Review
- Di-(2-ethylhexyl) phthalate-induced tumor growth is regulated by primary cilium formation via the axis of HInternational journal of medical sciences · 2021Article
- Cytoskeletal Remodeling in Cancer.Biology · 2020Review
- Thymosin‑β 4 induces angiogenesis in critical limb ischemia mice via regulating Notch/NF‑κB pathway.International journal of molecular medicine · 2020Article
- TMSB10 acts as a biomarker and promotes progression of clear cell renal cell carcinoma.International journal of oncology · 2020Article
- Thymosin β-4 is a novel regulator for primary cilium formation by nephronophthisis 3 in HeLa human cervical cancer cells.Scientific reports · 2019Article
- Global Proteomics-based Identification and Validation of Thymosin Beta-4 X-Linked as a Prognostic Marker for Head and Neck Squamous Cell Carcinoma.Scientific reports · 2017Article
- Tumor suppressor miR-1 inhibits tumor growth and metastasis by simultaneously targeting multiple genes.Oncotarget · 2017Article
- Thymosin β4 overexpression regulates neuron production and spatial distribution in the developing avian optic tectum.Histochemistry and cell biology · 2017Article
- Increased Expression of Thymosin βJournal of pathology and translational medicine · 2017Article
- MALDI-imaging reveals thymosin beta-4 as an independent prognostic marker for colorectal cancer.Oncotarget · 2015Article
- Thymosin β4 promotes hepatoblastoma metastasis via the induction of epithelial-mesenchymal transition.Molecular medicine reports · 2015Article
- ATF4-dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis.The Journal of clinical investigation · 2015Article
- Potential role of thymosin Beta 4 in liver fibrosis.International journal of molecular sciences · 2015Review
- Inflammation-related carcinogenesis: current findings in epidemiological trends, causes and mechanisms.Yonago acta medica · 2014Review
- Article
- Verifiable hypotheses for thymosin β4-dependent and -independent angiogenic induction of Trichinella spiralis-triggered nurse cell formation.International journal of molecular sciences · 2013Review
- Proteomic signatures of acquired letrozole resistance in breast cancer: suppressed estrogen signaling and increased cell motility and invasiveness.Molecular & cellular proteomics : MCP · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 6 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We identified a thymosin-beta4 gene overexpression in malignant mouse fibrosarcoma cells (QRsP-30) that were derived from clonal weakly tumorigenic and nonmetastatic QR-32 cells by using a differential display method. Thymosin-beta4 is known as a 4.9-kd polypeptide that interacts with G-actin and functions as a major actin-sequestering protein in cells. All of the six malignant fibrosarcoma cell lines that have been independently converted from QR-32 cells expressed high levels of thymosin-beta4 mRNA and its expression in tumor cells was correlated with tumorigenicity and metastatic potential. Up-regulation of thymosin-beta4 in QR-32 cells (32-S) transfected with sense thymosin-beta4 cDNA converted the cells to develop tumors and formed numerous lung metastases in syngeneic C57BL/6 mice. In contrast, antisense thymosin-beta4 cDNA-transfected QRsP-30 (30-AS) cells reduced thymosin-beta4 expression, and significantly lost tumor formation and metastases to distant organs. Vector-alone transfected cells (32-V or 30-V cells) behaved like their parental cells. We observed that tumor cell motility, cell shape, and F-actin organization is regulated in proportion to the level of thymosin-beta4 expression. These findings indicate that thymosin-beta4 molecule regulates fibrosarcoma cell tumorigenicity and metastasis through actin-based cytoskeletal organization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.