ArticleThe American journal of pathology2002
CAP37, a novel inflammatory mediator: its expression in endothelial cells and localization to atherosclerotic lesions.
Article in The American journal of pathology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 60 citations in OpenAlex.
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- The Role of Nutraceuticals in Age-Related Ocular Diseases.Molecules (Basel, Switzerland) · 2025Review
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- Glymphatic System Pathology and Neuroinflammation as Two Risk Factors of Neurodegeneration.Cells · 2024Review
- Review
- The Dynamics of Circulating Heparin-Binding Protein: Implications for Its Use as a Biomarker.Journal of innate immunity · 2022Article
- Proteomic analysis of peripheral blood polymorphonuclear cells (PBMCs) reveals alteration of neutrophil extracellular trap (NET) components in uncontrolled diabetes.Molecular and cellular biochemistry · 2019Article
- Detection of circulating extracellular mRNAs by modified small-RNA-sequencing analysis.JCI insight · 2019Article
- The role of neutrophil granule proteins in neuroinflammation and Alzheimer's disease.Journal of neuroinflammation · 2018Review
- Partners in crime: neutrophils and monocytes/macrophages in inflammation and disease.Cell and tissue research · 2018Review
- Emerging Associations Between Neutrophils, Atherosclerosis, and Psoriasis.Current atherosclerosis reports · 2017Review
- The antimicrobial protein, CAP37, is upregulated in pyramidal neurons during Alzheimer's disease.Histochemistry and cell biology · 2015Article
- A multifunctional peptide based on the neutrophil immune defense molecule, CAP37, has antibacterial and wound-healing properties.Journal of leukocyte biology · 2015Article
- The multifaceted functions of neutrophils.Annual review of pathology · 2014Review
- CAP37 activation of PKC promotes human corneal epithelial cell chemotaxis.Investigative ophthalmology & visual science · 2013Article
- Inflammation and immune system interactions in atherosclerosis.Cellular and molecular life sciences : CMLS · 2013Review
- Increased plasma levels of heparin-binding protein in patients with acute respiratory distress syndrome.Critical care (London, England) · 2013Observational
- The complexity of arterial classical monocyte recruitment.Journal of innate immunity · 2013Review
- Human neutrophil peptides mediate endothelial-monocyte interaction, foam cell formation, and platelet activation.Arteriosclerosis, thrombosis, and vascular biology · 2011Article
- Distinct infiltration of neutrophils in lesion shoulders in ApoE-/- mice.The American journal of pathology · 2010Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Cationic antimicrobial protein of 37 kd (CAP37), originally isolated from human neutrophils, is an important multifunctional inflammatory mediator. Here we describe its localization within the vascular endothelium associated with atherosclerotic plaques. Evidence from in vitro immunocytochemical, Northern blot, and reverse transcriptase-polymerase chain reaction analysis indicates that CAP37 is induced in endothelial cells in response to inflammatory mediators. Endothelial-derived CAP37 shows sequence identity with an extensive region of neutrophil-derived CAP37. This is the first demonstration of endogenous endothelial CAP37, confirmed by sequence analysis. We suggest that, because of its induction and location in the endothelium and its known monocyte- and endothelial-activating capabilities, CAP37 has potential to modulate monocyte/endothelial dynamics at the vessel wall in inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.