ReviewCurrent rheumatology reports2002
Control of connective tissue gene expression by TGF beta: role of Smad proteins in fibrosis.
Review in Current rheumatology reports, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 80 citations in OpenAlex.
- Deciphering the myth of icariin and synthetic derivatives in improving erectile function from a molecular biology perspective: a narrative review.Translational andrology and urology · 2022Review
- KGF-1 accelerates wound contraction through the TGF-β1/Smad signaling pathway in a double-paracrine manner.The Journal of biological chemistry · 2019Article
- Extracellular Interactions between Fibulins and Transforming Growth Factor (TGF)-β in Physiological and Pathological Conditions.International journal of molecular sciences · 2018Review
- Islet transplantation improved penile tissue fibrosis in a rat model of type 1 diabetes.BMC endocrine disorders · 2018Article
- Scar management in burn injuries using drug delivery and molecular signaling: Current treatments and future directions.Advanced drug delivery reviews · 2018Review
- De-ubiquitinating enzyme, USP11, promotes transforming growth factor β-1 signaling through stabilization of transforming growth factor β receptor II.Cell death & disease · 2016Article
- Fibulin-2 is essential for angiotensin II-induced myocardial fibrosis mediated by transforming growth factor (TGF)-β.Laboratory investigation; a journal of technical methods and pathology · 2016Article
- Silver nanoparticles/chitosan oligosaccharide/poly(vinyl alcohol) nanofiber promotes wound healing by activating TGFβ1/Smad signaling pathway.International journal of nanomedicine · 2016Article
- Modifier genes and their effect on Duchenne muscular dystrophy.Current opinion in neurology · 2015Review
- Calcipotriol counteracts betamethasone-induced decrease in extracellular matrix components related to skin atrophy.Archives of dermatological research · 2014Article
- Cutaneous wound healing: recruiting developmental pathways for regeneration.Cellular and molecular life sciences : CMLS · 2013Review
- Rapamycin inhibits transforming growth factor β1-induced fibrogenesis in primary human lung fibroblasts.Yonsei medical journal · 2013Article
- Quantification of active and total transforming growth factor-β levels in serum and solid organ tissues by bioassay.BMC research notes · 2012Article
- Epithelial integrins with special reference to oral epithelia.Journal of dental research · 2011Review
- Effects of Haobie Yangyin Ruanjian decoction on hepatic fibrosis induced by carbon tetrachloride in rats.World journal of gastroenterology · 2010Article
- Advanced glycation end-products induce tubular CTGF via TGF-beta-independent Smad3 signaling.Journal of the American Society of Nephrology : JASN · 2010Article
- Increased cAMP levels modulate transforming growth factor-beta/Smad-induced expression of extracellular matrix components and other key fibroblast effector functions.The Journal of biological chemistry · 2010Article
- Interleukin (IL)-6 modulates transforming growth factor-beta expression in skin and dermal fibroblasts from IL-6-deficient mice.The British journal of dermatology · 2009Article
- The role of caveolin-1 in pulmonary matrix remodeling and mechanical properties.American journal of physiology. Lung cellular and molecular physiology · 2008Article
- Absence of alphavbeta6 integrin is linked to initiation and progression of periodontal disease.The American journal of pathology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transforming growth factor-beta (TGF beta) plays a critical role in the development of tissue fibrosis. Its expression is consistently elevated in affected organs and correlates with increased extracellular matrix deposition. During the last few years, tremendous progress has been made in understanding the molecular aspects of intracellular signaling downstream of the TGF beta receptors. In particular, Smad proteins--TGF beta receptor kinase substrates that translocate into the cell nucleus to act as transcription factors--have been studied extensively. Their role in the modulation of extracellular matrix gene expression is discussed in this review.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.