ArticleThe Journal of cell biology2002
Calcineurin-GATA-6 pathway is involved in smooth muscle-specific transcription.
Article in The Journal of cell biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 95 citations in OpenAlex.
- GATA6 and TBX3 gene expressions analysis of indirect inguinal hernia sacs in children.Pediatric surgery international · 2025Article
- GATA6 is a crucial factor for Myocd expression in the visceral smooth muscle cell differentiation program of the murine ureter.Development (Cambridge, England) · 2022Article
- Transcription factor GATA6 promotes migration of human coronary artery smooth muscle cellsFrontiers in physiology · 2022Article
- Calcineurin in the heart: New horizons for an old friend.Cellular signalling · 2021Review
- A Novel STAT3-Mediated GATA6 Pathway Contributes toOxidative medicine and cellular longevity · 2020Article
- Regulator of G protein signaling 4 is a novel target of GATA-6 transcription factor.Biochemical and biophysical research communications · 2017Article
- The cardiac calsequestrin gene transcription is modulated at the promoter by NFAT and MEF-2 transcription factors.PloS one · 2017Article
- Role of CaMKII in Ang-II-dependent small artery remodeling.Vascular pharmacology · 2016Article
- Nuclear factor of activated T-cell isoform expression and regulation in human myometrium.Reproductive biology and endocrinology : RB&E · 2015Article
- Reciprocal regulation controlling the expression of CPI-17, a specific inhibitor protein for the myosin light chain phosphatase in vascular smooth muscle cells.American journal of physiology. Cell physiology · 2012Article
- In vitro epigenetic reprogramming of human cardiac mesenchymal stromal cells into functionally competent cardiovascular precursors.PloS one · 2012Article
- Article
- Ure2 is involved in nitrogen catabolite repression and salt tolerance via Ca2+ homeostasis and calcineurin activation in the yeast Hansenula polymorpha.The Journal of biological chemistry · 2010Article
- Potential role of calcineurin in pathogenic conditions.Molecular and cellular biochemistry · 2010Review
- Cyclosporine up-regulates Krüppel-like factor-4 (KLF4) in vascular smooth muscle cells and drives phenotypic modulation in vivo.The Journal of pharmacology and experimental therapeutics · 2010Article
- Mechanisms of intermittent hypoxia induced hypertension.Journal of cellular and molecular medicine · 2010Review
- miR-145 directs intestinal maturation in zebrafish.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Regulation of soluble guanylyl cyclase-alpha1 expression in chronic hypoxia-induced pulmonary hypertension: role of NFATc3 and HuR.American journal of physiology. Lung cellular and molecular physiology · 2009Article
- GATA4 is a regulator of astrocyte cell proliferation and apoptosis in the human and murine central nervous system.Oncogene · 2009Article
- FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1.The Journal of cell biology · 2009Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intracellular calcium is one of the important signals that initiates the myogenic program. The calcium-activated phosphatase calcineurin is necessary for the nuclear import of the nuclear factor of activated T cell (NFAT) family members, which interact with zinc finger GATA transcription factors. Whereas GATA-6 plays a role in the maintenance of the differentiated phenotype in vascular smooth muscle cells (VSMCs), it is unknown whether the calcineurin pathway is associated with GATA-6 and plays a role in the differentiation of VSMCs. The smooth muscle-myosin heavy chain (Sm-MHC) gene is a downstream target of GATA-6, and provides a highly specific marker for differentiated VSMCs. Using immunoprecipitation Western blotting, we showed that NFATc1 interacted with GATA-6. Consistent with this, NFATc1 further potentiated GATA-6-activated Sm-MHC transcription. Induction of VSMCs to the quiescent phenotype caused nuclear translocation of NFATc1. In differentiated VSMCs, blockage of calcineurin down-regulated the amount of GATA-6-DNA binding as well as the expression of Sm-MHC and its transcriptional activity. These findings demonstrate that the calcineurin pathway is associated with GATA-6 and is required for the maintenance of the differentiated phenotype in VSMCs.
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