ArticleJournal of bacteriology2002
Conserved serine/threonine kinase encoded by CBK1 regulates expression of several hypha-associated transcripts and genes encoding cell wall proteins in Candida albicans.
Article in Journal of bacteriology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 49 citations in OpenAlex.
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- Regulation of Neurospora crassa cell wall remodeling via the cot-1 pathway is mediated by gul-1.Current genetics · 2017Article
- Control of Candida albicans morphology and pathogenicity by post-transcriptional mechanisms.Cellular and molecular life sciences : CMLS · 2016Review
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- Genome-wide synthetic genetic screening by transposon mutagenesis in Candida albicans.Methods in molecular biology (Clifton, N.J.) · 2015Article
- Cell cycle-independent phospho-regulation of Fkh2 during hyphal growth regulates Candida albicans pathogenesis.PLoS pathogens · 2015Article
- Efg1 directly regulates ACE2 expression to mediate cross talk between the cAMP/PKA and RAM pathways during Candida albicans morphogenesis.Eukaryotic cell · 2014Article
- Systematic phenotyping of a large-scale Candida glabrata deletion collection reveals novel antifungal tolerance genes.PLoS pathogens · 2014Article
- Reduced TOR signaling sustains hyphal development in Candida albicans by lowering Hog1 basal activity.Molecular biology of the cell · 2013Article
- Surface stress induces a conserved cell wall stress response in the pathogenic fungus Candida albicans.Eukaryotic cell · 2013Article
- The RAM network in pathogenic fungi.Eukaryotic cell · 2012Review
- The NDR/LATS kinase Cbk1 controls the activity of the transcriptional regulator Bcr1 during biofilm formation in Candida albicans.PLoS pathogens · 2012Article
- DNA mutations mediate microevolution between host-adapted forms of the pathogenic fungus Cryptococcus neoformans.PLoS pathogens · 2012Article
- Growth of Candida albicans hyphae.Nature reviews. Microbiology · 2011Review
- CDK-dependent phosphorylation of Mob2 is essential for hyphal development in Candida albicans.Molecular biology of the cell · 2011Article
- A large-scale complex haploinsufficiency-based genetic interaction screen in Candida albicans: analysis of the RAM network during morphogenesis.PLoS genetics · 2011Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The opportunistic fungal pathogen, Candida albicans, is reported to have several potential virulence factors. A potentially significant factor is the ability to undergo morphological transition from yeast to hypha. This alteration of form is accompanied by many changes within the cell, including alterations in gene expression and cell wall composition. We have isolated a gene that encodes a highly conserved serine/threonine kinase that appears to be involved in the regulation of proteins associated with the cell wall. We have assigned the designation CBK1 (cell wall biosynthesis kinase 1) to this gene. Mutants lacking CBK1 form large aggregates of round cells under all growth conditions and lack the ability to undergo morphological differentiation. Additionally, these mutants show an altered pattern of expression of several transcripts encoding proteins associated with the cell wall. The results suggest that the kinase encoded by CBK1 plays a general role in the maintenance and alteration of the cell wall of C. albicans in all morphologies.
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