ArticleThe EMBO journal2002
Crystal structures of two intermediates in the assembly of the papillomavirus replication initiation complex.
Article in The EMBO journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed.
- Thermodynamic variations at the HPV E1-E2 interface correlate with clinical risk groups: an in-silico analysis.Virology journal · 2026Article
- Structure, Function and Inhibition of Helicases Involved in Virus Infection.Biomolecules · 2026Review
- Structures of pMV158 replication initiator RepB with and without DNA reveal a flexible dual-function protein.Nucleic acids research · 2023Article
- Unwinding of a DNA replication fork by a hexameric viral helicase.Nature communications · 2021Article
- Article
- Structural and Functional Basis for an EBNA1 Hexameric Ring in Epstein-Barr Virus Episome Maintenance.Journal of virology · 2017Article
- Article
- Conformational plasticity of RepB, the replication initiator protein of promiscuous streptococcal plasmid pMV158.Scientific reports · 2016Article
- Structural Based Analyses of the JC Virus T-Antigen F258L Mutant Provides Evidence for DNA Dependent Conformational Changes in the C-Termini of Polyomavirus Origin Binding Domains.PLoS pathogens · 2016Article
- Structural basis for DNA strand separation by a hexameric replicative helicase.Nucleic acids research · 2015Article
- Evidence supporting a role for TopBP1 and Brd4 in the initiation but not continuation of human papillomavirus 16 E1/E2-mediated DNA replication.Journal of virology · 2015Article
- A conserved regulatory module at the C terminus of the papillomavirus E1 helicase domain controls E1 helicase assembly.Journal of virology · 2015Article
- Loading strategies of ring-shaped nucleic acid translocases and helicases.Current opinion in structural biology · 2014Review
- Dynamic look at DNA unwinding by a replicative helicase.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Recombination-dependent oligomerization of human papillomavirus genomes upon transient DNA replication.Journal of virology · 2013Article
- The E1 proteins.Virology · 2013Review
- CK2 phosphorylation inactivates DNA binding by the papillomavirus E1 and E2 proteins.Journal of virology · 2013Article
- A structural framework for replication origin opening by AAA+ initiation factors.Current opinion in structural biology · 2013Review
- Loading mechanisms of ring helicases at replication origins.Molecular microbiology · 2012Review
- A flexible brace maintains the assembly of a hexameric replicative helicase during DNA unwinding.Nucleic acids research · 2012Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Initiation of DNA replication of the papillomavirus genome is a multi-step process involving the sequential loading of viral E1 protein subunits onto the origin of replication. Here we have captured structural snapshots of two sequential steps in the assembly process. Initially, an E1 dimer binds to adjacent major grooves on one face of the double helix; a second dimer then binds to another face of the helix. Each E1 monomer has two DNA-binding modules: a DNA-binding loop, which binds to one DNA strand and a DNA-binding helix, which binds to the opposite strand. The nature of DNA binding suggests a mechanism for the transition between double- and single-stranded DNA binding that is implicit in the progression to a functional helicase.
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