ArticleThe EMBO journal2002
Promoter-specific functions of CIITA and the MHC class II enhanceosome in transcriptional activation.
Article in The EMBO journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- c-Rel-dependent monocytes are potent immune suppressor cells in cancer.Journal of leukocyte biology · 2022Article
- Generation and expression analysis of BAC humanized mice carrying HLA-DP401 haplotype.Animal models and experimental medicine · 2021Article
- The class I/IV HDAC inhibitor mocetinostat increases tumor antigen presentation, decreases immune suppressive cell types and augments checkpoint inhibitor therapy.Cancer immunology, immunotherapy : CII · 2018Article
- Article
- Blocking MHC class II on human endothelium mitigates acute rejection.JCI insight · 2016Article
- Common distal elements orchestrate CIITA isoform-specific expression in multiple cell types.Genes and immunity · 2014Article
- Regulation of MHC class I expression by Foxp3 and its effect on regulatory T cell function.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Expression regulation and function of NLRC5.Protein & cell · 2013Review
- Contrasting effects of IFNα on MHC class II expression in professional vs. nonprofessional APCs: Role of CIITA type IV promoter.Results in immunology · 2012Article
- Interferon-triggered transcriptional cascades in the oligodendroglial lineage: a comparison of induction of MHC class II antigen between oligodendroglial progenitor cells and mature oligodendrocytes.Journal of neuroimmunology · 2009Article
- Histone modifications, but not nucleosomal positioning, correlate with major histocompatibility complex class I promoter activity in different tissues in vivo.Molecular and cellular biology · 2008Article
- Identification of CIITA regulated genetic module dedicated for antigen presentation.PLoS genetics · 2008Article
- Transcription-coupled deposition of histone modifications during MHC class II gene activation.Nucleic acids research · 2007Article
- Coordinated changes of histone modifications and HDAC mobilization regulate the induction of MHC class II genes by Trichostatin A.Nucleic acids research · 2006Article
- New functions of the major histocompatibility complex class II-specific transcription factor RFXANK revealed by a high-resolution mutagenesis study.Molecular and cellular biology · 2005Article
- Coordinate enhancers share common organizational features in the Drosophila genome.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- CIITA regulates transcription onset viaSer5-phosphorylation of RNA Pol II.The EMBO journal · 2003Article
- Mutations in the HLA class II genes leading to loss of expression of HLA-DR and HLA-DQ in diffuse large B-cell lymphoma.Immunogenetics · 2003Article
- Histone deacetylase 1/mSin3A disrupts gamma interferon-induced CIITA function and major histocompatibility complex class II enhanceosome formation.Molecular and cellular biology · 2003Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcription of the major histocompatibility complex class II family of genes is regulated by conserved promoter elements and two gene-specific trans-activators, RFX and CIITA. RFX binds DNA and nucleates the assembly of an enhanceosome, which recruits CIITA through protein--protein interactions. Transcriptional activation is a complex, multi-step process involving chromatin modification and recruitment of the transcription apparatus. To examine the roles of the enhanceosome and CIITA in these processes, we analysed the level of promoter-associated hyperacetylated histones H3 and H4, TBP, TFIIB and RNA poly merase II in cells lacking RFX or CIITA. We compared four genes co-regulated by RFX and CIITA (HLA-DRA, HLA-DPB, HLA-DMB and Ii) and found that the enhanceosome and CIITA make variable, promoter-dependent contributions to histone acetylation and transcription apparatus recruitment. CIITA is generally implicated at multiple levels of the activation process, while the enhanceosome contributes in a CIITA-independent manner only at certain promoters. Our results support the general notion that the impact of a particular activator on transcription in vivo may vary depending on the promoter and the chromatin context.
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