ReviewThe EMBO journal2002
Addressing protein localization within the nucleus.
Review in The EMBO journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- Recent Advances in Proximity Labeling-Based Subcellular Proteomic Mapping.Molecular & cellular proteomics : MCP · 2026Review
- Epigenetic Modifications in the Retinal Pigment Epithelium of the Eye During RPE-Related Regeneration or Retinal Diseases in Vertebrates.Biomedicines · 2025Review
- Computational Approaches to Predict Protein-Protein Interactions in Crowded Cellular Environments.Chemical reviews · 2024Review
- Macromolecular Crowding as an Intracellular Stimulus for Responsive Nanomaterials.Journal of the American Chemical Society · 2022Article
- Functional characterization of Gh_A08G1120 (GH3.5) gene reveal their significant role in enhancing drought and salt stress tolerance in cotton.BMC genetics · 2019Article
- Detailed prediction of protein sub-nuclear localization.BMC bioinformatics · 2019Article
- Computational Approach for Structural Feature Determination of Grapevine NHX Antiporters.BioMed research international · 2019Article
- NLSdb-major update for database of nuclear localization signals and nuclear export signals.Nucleic acids research · 2018Article
- Insights from the Molecular Modelling and Docking Analysis of AIF-NLS complex to infer Nuclear Translocation of the Protein.Bioinformation · 2018Article
- UNcleProt (Universal Nuclear Protein database of barley): The first nuclear protein database that distinguishes proteins from different phases of the cell cycle.Nucleus (Austin, Tex.) · 2017Article
- Principles of protein targeting to the nucleolus.Nucleus (Austin, Tex.) · 2015Article
- The Role of Crowding Forces in Juxtaposing β-Globin Gene Domain Remote Regulatory Elements in Mouse Erythroid Cells.PloS one · 2015Article
- Macromolecular crowding as a regulator of gene transcription.Biophysical journal · 2014Article
- Re-evaluation of the role of calcium homeostasis endoplasmic reticulum protein (CHERP) in cellular calcium signaling.The Journal of biological chemistry · 2013Article
- Comparative analyses of nuclear proteome: extending its function.Frontiers in plant science · 2013Article
- Crowding effects on the formation and maintenance of nuclear bodies: insights from molecular-dynamics simulations of simple spherical model particles.Biophysical journal · 2012Article
- Sorting the nuclear proteome.Bioinformatics (Oxford, England) · 2011Article
- Article
- Hydrophilicity matching - a potential prerequisite for the formation of protein-protein complexes in the cell.PloS one · 2010Article
- Drosophila SAF-B links the nuclear matrix, chromosomes, and transcriptional activity.PloS one · 2010Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bridging the gap between the number of gene sequences in databases and the number of gene products that have been functionally characterized in any way is a major challenge for biology. A key characteristic of proteins, which can begin to elucidate their possible functions, is their subcellular location. A number of experimental approaches can reveal the subcellular localization of proteins in mammalian cells. However, genome databases now contain predicted sequences for a large number of potentially novel proteins that have yet to be studied in any way, let alone have their subcellular localization determined. Here we ask whether using bioinformatics tools to analyse the sequence of proteins whose subnuclear localizations have been determined can reveal characteristics or signatures that might allow us to predict localization for novel protein sequences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.