ArticleEuropean journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery2002
Selective opening of mitochondrial ATP-sensitive potassium channels during surgically induced myocardial ischemia decreases necrosis and apoptosis.
Article in European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 46 citations in OpenAlex.
- Diazoxide is a powerful cardioprotectant but is not feasible in a realistic infarct scenario.Frontiers in cardiovascular medicine · 2023Article
- ATP-Sensitive Potassium Channel Opener Diazoxide Reduces Myocardial Stunning in a Porcine Regional With Subsequent Global Ischemia Model.Journal of the American Heart Association · 2022Review
- Tanshinone‑IIA inhibits myocardial infarct via decreasing of the mitochondrial apoptotic signaling pathway in myocardiocytes.International journal of molecular medicine · 2021Article
- Intracoronary and peripheral blood levels of TNF-like Cytokine 1A (TL1A) in patients with acute coronary syndrome.Medicine · 2020Article
- Decoy receptor-3 regulates inflammation and apoptosis via PI3K/AKT signaling pathway in coronary heart disease.Experimental and therapeutic medicine · 2019Article
- Isoflurane reduces pain and inhibits apoptosis of myocardial cells through the phosphoinositide 3-kinase/protein kinase B signaling pathway in mice during cardiac surgery.Molecular medicine reports · 2018Article
- Article
- Curcumin inhibits proliferation of gastric cancer cells by impairing ATP-sensitive potassium channel opening.World journal of surgical oncology · 2014Article
- The effect of butorphanol postconditioning on myocardial ischaemia reperfusion injury in rats.Interactive cardiovascular and thoracic surgery · 2014Article
- Transplantation of autologously derived mitochondria protects the heart from ischemia-reperfusion injury.American journal of physiology. Heart and circulatory physiology · 2013Article
- Transcriptomic and proteomic analysis of global ischemia and cardioprotection in the rabbit heart.Physiological genomics · 2009Article
- Injection of isolated mitochondria during early reperfusion for cardioprotection.American journal of physiology. Heart and circulatory physiology · 2009Article
- Cardioplegia and diazoxide modulate STAT3 activation and DNA binding.The Annals of thoracic surgery · 2007Article
- Reduction of myocardial infarct size by doxycycline: a role for plasmin inhibition.Molecular and cellular biochemistry · 2005Article
- Diazoxide amelioration of myocardial injury and mitochondrial damage during cardiac surgery.The Annals of thoracic surgery · 2002Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveMitochondrial ATP-sensitive potassium channels have been proposed to be myoprotective. The relevance and specificity of this mechanism in cardiac surgery was unknown. The purpose of this study was to examine the effects of the mitochondrial potassium ATP-sensitive channel opener diazoxide on regional and global myocardial protection using a model of acute myocardial infarction.
methodsPigs (n=19) were placed on total cardiopulmonary bypass and then subjected to 30 min normothermic regional ischemia by snaring the left anterior descending coronary artery (LAD). The aorta was then crossclamped and cold blood Deaconess Surgical Associates cardioplegia (DSA; n=6) or DSA containing 50 microM diazoxide (DZX; n=6) was delivered via the aortic root and the hearts subjected to 30 min hypothermic global ischemia. The crossclamp and snare were removed and the hearts reperfused for 120 min.
resultsNo significant differences in preload recruitable stroke work relationship, Tau, proximal, distal or proximal/distal coronary flow, regional or global segmental shortening, systolic bulging or post-systolic shortening were observed within or between DSA and DZX hearts during reperfusion. Infarct was present only in the region of LAD occlusion in both DSA and DZX hearts. Infarct size (% of area at risk) was 33.6+/-2.9% in DSA and was 16.8+/-2.4% in DZX hearts (P<0.01 versus DSA). Apoptosis as estimated by TUNEL positive nuclei was 120.3+/-48.8 in DSA and was significantly decreased to 21.4+/-5.3 in DZX hearts. Myocardial infarct was located centrally within the area at risk in both DSA and DZX hearts but was significantly increased at borderline zones within the area at risk in DSA hearts.
conclusionsThe addition of diazoxide to cardioplegia significantly decreases regional myocardial cell necrosis and apoptosis in a model of acute myocardial infarction and represents an additional modality for achieving myocardial protection.
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