ArticleEndocrine2001
Urinary vasodilator and vasoconstrictor angiotensins during menstrual cycle, pregnancy, and lactation.
Article in Endocrine, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 72 citations in OpenAlex.
- Embracing sex-specific differences in engineered kidney models for enhanced biological understanding of kidney function.Biology of sex differences · 2024Review
- SARS- CoV-2 infection and oxidative stress in early-onset preeclampsia.Biochimica et biophysica acta. Molecular basis of disease · 2022Review
- The Involvement of MicroRNAs in SARS-CoV-2 Infection Comorbid with HIV-Associated Preeclampsia.Current hypertension reports · 2021Review
- Article
- Local angiotensin-(1-7) administration improves microvascular endothelial function in women who have had preeclampsia.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Sex differences in endothelial function important to vascular health and overall cardiovascular disease risk across the lifespan.American journal of physiology. Heart and circulatory physiology · 2018Review
- The role of ACE2, angiotensin-(1-7) and Mas1 receptor axis in glucocorticoid-induced intrauterine growth restriction.Reproductive biology and endocrinology : RB&E · 2017Article
- Dose-dependent effects of angiotensin-(1-7) on the NHE3 exchanger and [Ca(2+)](i) in in vivo proximal tubules.American journal of physiology. Renal physiology · 2013Article
- Matrix metalloproteinases as drug targets in preeclampsia.Current drug targets · 2013Review
- Utero-placental expression of angiotensin-(1-7) and ACE2 in the pregnant guinea-pig.Reproductive biology and endocrinology : RB&E · 2013Article
- Renin-angiotensin system in pre-eclampsia: everything old is new again.Obstetric medicine · 2012Review
- GPCRs as potential therapeutic targets in preeclampsia.Drug discovery today. Disease models · 2012Article
- Challenges posed to the maternal circulation by pregnancy.Integrated blood pressure control · 2011Article
- Angiotensin II and angiotensin-(1-7) decrease sFlt1 release in normal but not preeclamptic chorionic villi: an in vitro study.Reproductive biology and endocrinology : RB&E · 2010Article
- Advances in the renin angiotensin system focus on angiotensin-converting enzyme 2 and angiotensin-(1-7).Advances in pharmacology (San Diego, Calif.) · 2010Article
- Vasodilator factors in the systemic and local adaptations to pregnancy.Reproductive biology and endocrinology : RB&E · 2009Review
- Systemic and uteroplacental renin--angiotensin system in normal and pre-eclamptic pregnancies.Therapeutic advances in cardiovascular disease · 2008Review
- New angiotensins.Journal of molecular medicine (Berlin, Germany) · 2008Review
- AT1-receptor autoantibodies and uteroplacental RAS in pregnancy and pre-eclampsia.Journal of molecular medicine (Berlin, Germany) · 2008Review
- Activation of local chorionic villi angiotensin II levels but not angiotensin (1-7) in preeclampsia.Hypertension (Dallas, Tex. : 1979) · 2008Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Since normal human pregnancy is characterized by normotension in the face of an increased renin-angiotensin-aldosterone system (RAAS), we evaluated the temporal pattern of urinary excretion of a novel vasodilator within this system, angiotensin-(1-7) (Ang-[1-7]), during the menstrual cycle, pregnancy, and lactation. The urinary profiles of Ang I, Ang II, human chorionic gonadotropin, 17beta-estradiol, and progesterone were also determined. During the menstrual cycle, urinary Ang-(1-7) and Ang II remained stable (mean cycle value: 94.6 +/- 11.3 and 11.4 +/- 1.1 pmol/g of creatinine, respectively) in nine females. In 10 normal pregnant women, urinary Ang-(1-7) and Ang II increased throughout gestation, averaging 1499.8 +/- 310 and 224.4 +/- 58 pmol/g of creatinine, respectively (p < 0.05) at wk 35 and falling during lactation to 394.0 +/- 95 and 65.7 +/- 20 pmol/ g of creatinine (p < 0.05), respectively. The Ang-(1-7)/Ang II ratio was unchanged in the different reproductive periods. During the menstrual cycle, Ang II and Ang-(1-7) correlated with 17beta-estradiol and progesterone using multivariate analysis (r = 0.31, p < 0.001) and r = 0.28, p < 0.02, respectively). During gestation, 17beta-estradiol and progesterone correlated with urinary Ang-(1-7) (r = 0.48, p < 0.001 and r = 0.47, p < 0.001, respectively) and Ang II (r = 0.24, p < 0.03 and r = 0.25, p < 0.03, respectively); by multiple regression, only Ang-(1-7) correlated with both steroids (r = 0.49,p < 0.001). The progressive rise of Ang-(1-7) throughout gestation, probably modulated by estrogen and progesterone, suggests a physiologic counterregulation within the RAAS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.