ArticleNucleic acids research2002
Hierarchical high-throughput SNP genotyping of the human Y chromosome using MALDI-TOF mass spectrometry.
Article in Nucleic acids research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Trial
- Y-chromosome descent clusters and male differential reproductive success: young lineage expansions dominate Asian pastoral nomadic populations.European journal of human genetics : EJHG · 2015Article
- Inferring population structure and relationship using minimal independent evolutionary markers in Y-chromosome: a hybrid approach of recursive feature selection for hierarchical clustering.Nucleic acids research · 2014Article
- Gene conversion violates the stepwise mutation model for microsatellites in y-chromosomal palindromic repeats.Human mutation · 2014Article
- Multiplex single-nucleotide polymorphism typing of the human Y chromosome using TaqMan probes.Investigative genetics · 2011Article
- The Y-chromosome landscape of the Philippines: extensive heterogeneity and varying genetic affinities of Negrito and non-Negrito groups.European journal of human genetics : EJHG · 2011Article
- Rapid genotyping of single nucleotide polymorphisms influencing warfarin drug response by surface-enhanced laser desorption and ionization time-of-flight (SELDI-TOF) mass spectrometry.The Journal of molecular diagnostics : JMD · 2010Article
- Simple, efficient, and cost-effective multiplex genotyping with matrix assisted laser desorption/ionization time-of-flight mass spectrometry of hemoglobin beta gene mutations.The Journal of molecular diagnostics : JMD · 2009Article
- Phenotypic variation within European carriers of the Y-chromosomal gr/gr deletion is independent of Y-chromosomal background.Journal of medical genetics · 2009Article
- Dynamic nature of the proximal AZFc region of the human Y chromosome: multiple independent deletion and duplication events revealed by microsatellite analysis.Human mutation · 2008Article
- Y-chromosomal insights into the genetic impact of the caste system in India.Human genetics · 2007Article
- Structural variation on the short arm of the human Y chromosome: recurrent multigene deletions encompassing Amelogenin Y.Human molecular genetics · 2007Article
- Matrix-assisted laser desorption/ionisation, time-of-flight mass spectrometry in genomics research.PLoS genetics · 2006Review
- Male demography in East Asia: a north-south contrast in human population expansion times.Genetics · 2006Article
- Multiplex PCR for the assignment of some major branches of the Y chromosome tree.Journal of genetics · 2005Article
- The dual origin of the Malagasy in Island Southeast Asia and East Africa: evidence from maternal and paternal lineages.American journal of human genetics · 2005Article
- Parallel minisequencing followed by multiplex matrix-assisted laser desorption/ionization mass spectrometry assay for beta-thalassemia mutations.Journal of human genetics · 2005Article
- Y chromosome haplogroups of elite Ethiopian endurance runners.Human genetics · 2004Article
- Y chromosomal haplogroup J as a signature of the post-neolithic colonization of Europe.Human genetics · 2004Article
- A predominantly neolithic origin for Y-chromosomal DNA variation in North Africa.American journal of human genetics · 2004Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have established the use of a primer extension/mass spectrometry method (the PinPoint assay) for high-throughput SNP genotyping of the human Y chromosome. 118 markers were used to define 116 haplogroups and typing was organised in a hierarchical fashion. Twenty multiplex PCR/primer extension reactions were set up and each sample could be assigned to a haplogroup with only two to five of these multiplex analyses. A single aliquot of one enzyme was found to be sufficient for both PCR and primer extension. We observed 100% accuracy in blind validation tests. The technique thus provides a reliable, cost-effective and automated method for Y genotyping, and the advantages of using a hierarchical strategy can be applied to any DNA segment lacking recombination.
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