ArticleNucleic acids research2002
Differential expression and requirements for Schizosaccharomyces pombe RAD52 homologs in DNA repair and recombination.
Article in Nucleic acids research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Microarray analysis of p-anisaldehyde-induced transcriptome of Saccharomyces cerevisiae.Journal of industrial microbiology & biotechnology · 2010Article
- Genetic analysis reveals different roles of Schizosaccharomyces pombe sfr1/dds20 in meiotic and mitotic DNA recombination and repair.Current genetics · 2008Article
- Article
- Meiotic Recombination in Schizosaccharomyces pombe: A Paradigm for Genetic and Molecular Analysis.Genome dynamics and stability · 2008Article
- Microhomology-mediated end joining in fission yeast is repressed by pku70 and relies on genes involved in homologous recombination.Genetics · 2007Article
- The F-Box DNA helicase Fbh1 prevents Rhp51-dependent recombination without mediator proteins.Molecular and cellular biology · 2005Article
- Role of the fission yeast SUMO E3 ligase Pli1p in centromere and telomere maintenance.The EMBO journal · 2004Article
- Article
- DNA repair functions that control sensitivity to topoisomerase-targeting drugs.Eukaryotic cell · 2004Article
- DNA repair by a Rad22-Mus81-dependent pathway that is independent of Rhp51.Nucleic acids research · 2004Article
- Five RecA-like proteins of Schizosaccharomyces pombe are involved in meiotic recombination.Genetics · 2003Article
- Schizosaccharomyces pombe Rdh54 (TID1) acts with Rhp54 (RAD54) to repair meiotic double-strand breaks.Molecular biology of the cell · 2003Article
- Nuclear factories for signalling and repairing DNA double strand breaks in living fission yeast.Nucleic acids research · 2003Article
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6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In fission yeast two RAD52 homologs have been identified, rad22A(+) and rad22B(+). Two-hybrid experiments and GST pull-down assays revealed physical interaction between Rad22A and Rad22B, which is dependent on the N-terminal regions. Interaction with Rhp51 is dependent on the C-terminal parts of either protein. Both Rad22A and Rad22B also interact with RPA. The expression of rad22B(+) in mitotically dividing cells is very low in comparison with rad22A(+) but is strongly enhanced after induction of meiosis, in contrast to rad22A(+). Rad22B mutant cells are not hypersensitive to DNA-damaging agents (X-rays, UV and cisplatin) and display normal levels of recombination. In these respects the Schizosaccharomyces pombe rad22B mutant resembles the weak phenotype of vertebrate cells deficient for RAD52. Mutation of rad22A(+) leads to severe sensitivity to DNA-damaging agents and to defects in recombination. In a rad22Arad22B double mutant a further increase in sensitivity to DNA-damaging agents and additional mitotic recombination defects were observed. The data presented here indicate that Rad22A and Rad22B have overlapping roles in repair and recombination, although specialized functions for each protein cannot be excluded.
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