ArticleMolecular and cellular biology2002
Regulation of E2F1-dependent gene transcription and apoptosis by the ETS-related transcription factor GABPgamma1.
Article in Molecular and cellular biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- GABPB1 plays a cancer-promoting role in non-small cell lung cancer.Discover oncology · 2024Article
- The ETS family member GABPα modulates androgen receptor signalling and mediates an aggressive phenotype in prostate cancer.Nucleic acids research · 2014Article
- Regulation of E2F1-induced apoptosis by the nucleolar protein RRP1B.The Journal of biological chemistry · 2010Article
- Subconjunctival gene delivery of the transcription factor GA-binding protein delays corneal neovascularization in a mouse model.Gene therapy · 2009Article
- The rb pathway and cancer therapeutics.Current drug targets · 2009Review
- GABPbeta2 is dispensible for normal lymphocyte development but moderately affects B cell responses.The Journal of biological chemistry · 2008Article
- Targeting the GA binding protein beta1L isoform does not perturb lymphocyte development and function.Molecular and cellular biology · 2008Article
- Life and death decisions by the E2F transcription factors.Current opinion in cell biology · 2007Review
- Jab1 is a specificity factor for E2F1-induced apoptosis.Genes & development · 2006Article
- The E2F family: specific functions and overlapping interests.The EMBO journal · 2004Review
- Regulation of mGluR1 expression in human melanocytes and melanoma cells.Biochimica et biophysica actaArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The E2F family of transcription factors comprises six related members which are involved in the control of the coordinated progression through the G(1)/S-phase transition of cell cycle or in cell fate decision. Their activity is regulated by pocket proteins, including pRb, p107, and p130. Here we show that E2F1 directly interacts with the ETS-related transcription factor GABPgamma1 in vitro and in vivo. The binding domain interacting with GABPgamma1 was mapped to the C-terminal amino acids 310 to 437 of E2F1, which include its transactivation and pRb binding domain. Among the E2F family of transcription factors, the interaction with GABPgamma1 is restricted to E2F1. DNA-binding E2F1 complexes containing GABPgamma1 are characterized by enhanced E2F1-dependent transcriptional activity. Moreover, GABPgamma1 suppresses E2F1-dependent apoptosis by mechanisms other than the inhibition of the transactivation capacity of E2F1. In summary, our results provide evidence for a novel pRb-independent mechanism regulating E2F1-dependent transcription and apoptosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.