ArticleMolecular and cellular biology2002
Shared role for differentially methylated domains of imprinted genes.
Article in Molecular and cellular biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 56 citations in OpenAlex.
- A new class of human CpG Island promoters with primate-specific repeats.Scientific reports · 2025Article
- Loss of inherited genomic imprints in mice leads to severe disruption in placental lipid metabolism.Placenta · 2015Article
- Identification of Ssm1b, a novel modifier of DNA methylation, and its expression during mouse embryogenesis.Development (Cambridge, England) · 2014Article
- Generalized disruption of inherited genomic imprints leads to wide-ranging placental defects and dysregulated fetal growth.Developmental biology · 2013Article
- Semen samples showing an increased rate of spermatozoa with imprinting errors have a negligible effect in the outcome of assisted reproduction techniques.Epigenetics · 2012Article
- Choline nutrition programs brain development via DNA and histone methylation.Central nervous system agents in medicinal chemistry · 2012Review
- Impact of DNA methylation on trophoblast function.Clinical epigenetics · 2011Article
- The effects of dietary choline.Neuroscience bulletin · 2011Review
- Distinct roles of DMAP1 in mouse development.Molecular and cellular biology · 2011Article
- Article
- Methylation profiling in individuals with uniparental disomy identifies novel differentially methylated regions on chromosome 15.Genome research · 2010Article
- DNA methylation errors at imprinted loci after assisted conception originate in the parental sperm.European journal of human genetics : EJHG · 2009Article
- A randomly integrated transgenic H19 imprinting control region acquires methylation imprinting independently of its establishment in germ cells.Molecular and cellular biology · 2009Article
- DNA methyltransferase 1o functions during preimplantation development to preclude a profound level of epigenetic variation.Developmental biology · 2008Article
- Antagonism between DNA and H3K27 methylation at the imprinted Rasgrf1 locus.PLoS genetics · 2008Article
- Article
- Article
- Prenatal choline deficiency increases choline transporter expression in the septum and hippocampus during postnatal development and in adulthood in rats.Brain research · 2007Article
- Genomic imprinting in mammals: emerging themes and established theories.PLoS genetics · 2006Review
- Specific differentially methylated domain sequences direct the maintenance of methylation at imprinted genes.Molecular and cellular biology · 2006Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For most imprinted genes, a difference in expression between the maternal and paternal alleles is associated with a corresponding difference in DNA methylation that is localized to a differentially methylated domain (DMD). Removal of a gene's DMD leads to a loss of imprinting. These observations suggest that DMDs have a determinative role in genomic imprinting. To examine this possibility, we introduced sequences from the DMDs of the imprinted Igf2r, H19, and Snrpn genes into a nonimprinted derivative of the normally imprinted RSVIgmyc transgene, created by excising its own DMD. Hybrid transgenes with sequences from the Igf2r DMD2 were consistently imprinted, with the maternal allele being more methylated than the paternal allele. Only the repeated sequences within DMD2 were required for imprinting these transgenes. Hybrid transgenes containing H19 and Snrpn DMD sequences and ones containing sequences from the long terminal repeat of a murine intracisternal A particle retrotransposon were not imprinted. The Igf2r hybrid transgenes are comprised entirely of mouse genomic DNA and behave as endogenous imprinted genes in inbred wild-type and mutant mouse strains. These types of hybrid transgenes can be used to elucidate the functions of DMD sequences in genomic imprinting.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.