ArticleJournal of virology2002
Intra- and intercellular trafficking of the foamy virus auxiliary bet protein.
Article in Journal of virology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Article
- Foamy Viruses, Bet, and APOBEC3 Restriction.Viruses · 2021Review
- Review
- Article
- Mechanisms of alpha-synuclein action on neurotransmission: cell-autonomous and non-cell autonomous role.Biomolecules · 2015Review
- Identification and functional characterization of Bet protein as a negative regulator of BFV3026 replication.Virus genes · 2014Article
- Characterization of a full-length infectious clone of bovine foamy virus 3026.Virologica Sinica · 2014Article
- Review
- Immunisation with foamy virus Bet fusion proteins as novel strategy for HIV-1 epitope delivery.Immunologic research · 2013Article
- Unconventional secretion of Ebola virus matrix protein VP40.The Journal of infectious diseases · 2011Article
- Autophagy: a broad role in unconventional protein secretion?Trends in cell biology · 2011Article
- Protein folding does not prevent the nonclassical export of FGF1 and S100A13.Biochemical and biophysical research communications · 2009Article
- Secretion without Golgi.Journal of cellular biochemistry · 2008Review
- Anti-viral RNA silencing: do we look like plants?Retrovirology · 2006Review
- Restriction of foamy viruses by APOBEC cytidine deaminases.Journal of virology · 2006Article
- Intravesicular localization and exocytosis of alpha-synuclein and its aggregates.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- The antiretroviral activity of APOBEC3 is inhibited by the foamy virus accessory Bet protein.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Persistent infection with primate foamy virus type 1 increases human immunodeficiency virus type 1 cell binding via a Bet-independent mechanism.Journal of virology · 2004Article
- Early steps of retrovirus replicative cycle.Retrovirology · 2004Review
- Further characterization of equine foamy virus reveals unusual features among the foamy viruses.Journal of virology · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Bet protein of foamy viruses (FVs) is an auxiliary protein encoded by the 3' end of the viral genome. Although its function during the viral replication cycle is still unknown, Bet seems to play a key role in the establishment and/or maintenance of viral persistence, representing the predominant viral protein detected during chronic infection. To clarify the function of this viral protein, the subcellular distribution of Bet from the prototypic human foamy virus (HFV) was examined. We report here that this protein is distributed in both the cytoplasm and the nucleus of HFV-infected or Bet-transfected cells. The nuclear targeting results from the presence of a bipartite nuclear localization signal at the C-terminal region, sufficient to direct heterologous reporter proteins to the nucleus. Since HFV Bet spreads between cells, we show here that the secreted protein targets the nuclei of recipient cells. HFV Bet follows an unconventional route to exit the cell since its secretion is not affected by brefeldin A, a drug which disrupts the trafficking between the endoplasmic reticulum and the Golgi complex. Finally, these inter- and intracellular movements were also observed for the equine foamy virus Bet protein, strongly suggesting that these remarkable features are conserved among FVs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.