ArticleJournal of immunology (Baltimore, Md. : 1950)2002
Two new isotype-specific switching activities detected for Ig class switching.
Article in Journal of immunology (Baltimore, Md. : 1950), 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- Differential regulation of immunoglobulin class switch recombination by the tumor suppressor p53.Scientific reports · 2026Article
- Absent the pre-B cell receptor checkpoint, the B-1a immunoglobulin CDR-H3 repertoire normalizes by convergent selection.Frontiers in immunology · 2026Article
- Expression of IgA class switching gene in tonsillar mononuclear cells in patients with IgA nephropathy.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2011Article
- Switch region identity plays an important role in Ig class switch recombination.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- S region sequence, RNA polymerase II, and histone modifications create chromatin accessibility during class switch recombination.The Journal of experimental medicine · 2009Article
- Sgamma3 switch sequences function in place of endogenous Sgamma1 to mediate antibody class switching.The Journal of experimental medicine · 2008Article
- Expression of AID transgene is regulated in activated B cells but not in resting B cells and kidney.Molecular immunology · 2008Article
- Identification of murine B cell lines that undergo somatic hypermutation focused to A:T and G:C residues.European journal of immunology · 2008Article
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- Imprinting the fate of antigen-reactive B cells through the affinity of the B cell receptor.Journal of immunology (Baltimore, Md. : 1950) · 2006Article
- NF-kappa B binds to the immunoglobulin S gamma 3 region in vivo during class switch recombination.European journal of immunology · 2006Article
- AID-dependent histone acetylation is detected in immunoglobulin S regions.The Journal of experimental medicine · 2006Article
- Comparison of asthma phenotypes using different sensitizing protocols in mice.The Korean journal of internal medicine · 2005Article
- Mutational activity in cell line WEHI-231.Immunogenetics · 2005Article
- Differential regulation of histone acetylation and generation of mutations in switch regions is associated with Ig class switching.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Mapping of a functional recombination motif that defines isotype specificity for mu-->gamma3 switch recombination implicates NF-kappaB p50 as the isotype-specific switching factor.The Journal of experimental medicine · 2004Article
- Mutations occur in the Ig Smu region but rarely in Sgamma regions prior to class switch recombination.The EMBO journal · 2003Article
- Mlh1 can function in antibody class switch recombination independently of Msh2.The Journal of experimental medicine · 2003Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Ig class switch recombination (CSR) occurs by an intrachromosomal deletional process between switch (S) regions in B cells. To facilitate the study of CSR, we derived a new B cell line, 1.B4.B6, which is uniquely capable of mu --> gamma3, mu --> epsilon, and mu --> alpha, but not mu --> gamma1 CSR at its endogenous loci. The 1.B4.B6 cell line was used in combination with plasmid-based isotype-specific S substrates in transient transfection assays to test for the presence of trans-acting switching activities. The 1.B4.B6 cell line supports mu --> gamma3, but not mu --> gamma1 recombination, on S substrates. In contrast, normal splenic B cells activated with LPS and IL-4 are capable of plasmid-based mu --> gamma1 CSR and demonstrate that this S plasmid is active. Activation-induced deaminase (AID) was used as a marker to identify existing B cell lines as possible candidates for supporting CSR. The M12 and A20 cell lines were identified as AID positive and, following activation with CD40L and other activators, were found to differentially support mu --> epsilon and mu --> alpha plasmid-based CSR. These studies provide evidence for two new switching activities for mu --> gamma1 and mu --> epsilon CSR, which are distinct from mu --> gamma3 and mu --> alpha switching activities previously described. AID is expressed in all the B cell lines capable of CSR, but cannot account for the isotype specificity defined by the S plasmid assay. These results are consistent with a model in which isotype-specific switching factors are either isotype-specific recombinases or DNA binding proteins with sequence specificity for S DNA.
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