ArticleThe Journal of physiology2002
Membrane potential bistability is controlled by the hyperpolarization-activated current I(H) in rat cerebellar Purkinje neurons in vitro.
Article in The Journal of physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers.
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Who cites it
89 citing papers in PubMed.
- Cerebellar microcircuits enable robust evidence-based decisions through cortico-cerebellar coupling.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- HCAR1-mediated lactate signaling modulates motor behavior and regulates spontaneous firing in Purkinje cells.iScience · 2026Article
- Noise or signal? Spontaneous activity of dorsal horn neurons: patterns and function in health and disease.Pflugers Archiv : European journal of physiology · 2024Review
- In Vitro Patch-Clamp.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Multistability of bursting rhythms in a half-center oscillator and the protective effects of synaptic inhibition.Frontiers in cellular neuroscience · 2024Article
- Article
- KCa1.1 channels contribute to optogenetically driven post-stimulation silencing in cerebellar molecular layer interneurons.The Journal of general physiology · 2023Article
- Cannabidiol and Sodium Channel Pharmacology: General Overview, Mechanism, and Clinical Implications.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2022Review
- Weak Cation Selectivity in HCN Channels Results From KFunction (Oxford, England) · 2022Article
- Cannabidiol inhibits the skeletal muscle Nav1.4 by blocking its pore and by altering membrane elasticity.The Journal of general physiology · 2021Article
- Communication from the cerebellum to the neocortex during sleep spindles.Progress in neurobiology · 2021Article
- Bistability of somatic pattern memories: stochastic outcomes in bioelectric circuits underlying regeneration.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Is Purkinje Neuron Hyperpolarisation Important for Cerebellar Synaptic Plasticity? A Retrospective and Prospective Analysis.Cerebellum (London, England) · 2020Review
- Pogz deficiency leads to transcription dysregulation and impaired cerebellar activity underlying autism-like behavior in mice.Nature communications · 2020Article
- Cardiac and neuronal HCN channelopathies.Pflugers Archiv : European journal of physiology · 2020Review
- The Role of Early Bioelectric Signals in the Regeneration of Planarian Anterior/Posterior Polarity.Biophysical journal · 2019Article
- Cyproheptadine Regulates Pyramidal Neuron Excitability in Mouse Medial Prefrontal Cortex.Neuroscience bulletin · 2018Article
- Purkinje Cell Signaling Deficits in Animal Models of Ataxia.Frontiers in synaptic neuroscience · 2018Review
- Propensity for Bistability of Bursting and Silence in the Leech Heart Interneuron.Frontiers in computational neuroscience · 2018Article
- Serotonergic transmission at Merkel discs: modulation by exogenously applied chemical messengers and involvement of IJournal of neurochemistry · 2017Article
29 more citing papers are in PubMed but not listed here.
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4 authors.
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Abstract
We investigated the role of the hyperpolarization-activated mixed cation current, I(H), in the control of spontaneous action potential firing of rat cerebellar Purkinje neurons in brain slices. Extracellular recordings revealed that the continual action potential firing of Purkinje neurons was disrupted by the pharmacological blockade of I(H). Blockade of I(H) revealed spontaneous transitions between periods of tonic action potential firing and quiescence, without effects on the frequency or variance of action potential generation. Whole-cell recordings revealed that blockade of I(H) unmasked a form of membrane potential bistability, where transitions between tonic firing and quiescent states (separated by approximately 20 mV) were evoked by excitatory and inhibitory postsynaptic potentials, or by the delivery of brief (20 ms) somatic or dendritic positive and negative current pulses. The stable upper state of tonic action potential firing was maintained by the recruitment of axo-somatic voltage-activated sodium, but not calcium, channels. Negative modulation of I(H) by serotonin unmasked bistability, indicating that bistability of Purkinje neurons is likely to occur under physiological conditions. These data indicate that I(H) acts as a 'safety net', maintaining the membrane potential of Purkinje neurons within the range necessary for the generation of tonic action potential firing. Following the downregulation of I(H), synaptic inhibition can generate long periods (seconds) of quiescence, the duration of which can be controlled by climbing fibre activation and by the underlying 'tone' of parallel fibre activity.
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