ArticleBMC medical genetics2002
The Siblings With Ischemic Stroke Study (SWISS) protocol.
Article in BMC medical genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 4 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- Pooled it
- Meta-Analysis of Genome-Wide Association Studies Identifies Genetic Risk Factors for Stroke in African Americans.Stroke · 2015Pooled it
- Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials.Lancet (London, England) · 2011Pooled it
- Genomic risk profiling of ischemic stroke: results of an international genome-wide association meta-analysis.PloS one · 2011Pooled it
- The impact of privacy protections on recruitment in a multicenter stroke genetics study.Neurology · 2005Trial
- The Ischemic Stroke Genetics Study (ISGS) Protocol.BMC neurology · 2003Trial
- Rare coding variation and stroke heterogeneity in Saudi Arabia: an exome‑wide association study across severity, etiology, vascular territory, and early‑onset disease.BMC neurology · 2026Article
- Carotid Intima-Media Thickness, Genetic Risk, and Ischemic Stroke: A Family-Based Study in Rural China.International journal of environmental research and public health · 2020Article
- Interaction between an ATP-Binding Cassette A1 (ABCA1) Variant and Egg Consumption for the Risk of Ischemic Stroke and Carotid Atherosclerosis: a Family-Based Study in the Chinese Population.Journal of atherosclerosis and thrombosis · 2019Article
- Joint Effects of PON1 Polymorphisms and Vegetable Intake on Ischemic Stroke: A Family-Based Case Control Study.International journal of molecular sciences · 2017Article
- Genomics, Biology, and Human Illness: Advances in the Monogenic Autoinflammatory Diseases.Rheumatic diseases clinics of North America · 2017Review
- Validation of the 8-item questionnaire for verifying stroke free status with and without pictograms in three West African languages.eNeurologicalSci · 2016Article
- Multilingual Validation of the Questionnaire for Verifying Stroke-Free Status in West Africa.Stroke · 2016Article
- Early-onset stroke and vasculopathy associated with mutations in ADA2.The New England journal of medicine · 2014Article
- Article
- Genetic variants associated with myocardial infarction in the PSMA6 gene and Chr9p21 are also associated with ischaemic stroke.European journal of neurology · 2013Article
- Rare variants in ischemic stroke: an exome pilot study.PloS one · 2012Article
- Article
- Bio-Repository of DNA in stroke (BRAINS): a study protocol.BMC medical genetics · 2011Article
- Common mitochondrial sequence variants in ischemic stroke.Annals of neurology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundFamily history and twins studies suggest an inherited component to ischemic stroke risk. Candidate gene association studies have been performed but have limited capacity to identify novel risk factor genes. The Siblings With Ischemic Stroke Study (SWISS) aims to conduct a genome-wide scan in sibling pairs concordant or discordant for ischemic stroke to identify novel genetic risk factors through linkage analysis.
methodsScreening at multiple clinical centers identifies patients (probands) with radiographically confirmed ischemic stroke and a family history of at least 1 living full sibling with stroke. After giving informed consent, without violating privacy among other family members, the proband invites siblings concordant and discordant for stroke to participate. Siblings then contact the study coordinating center. The diagnosis of ischemic stroke in potentially concordant siblings is confirmed by systematic centralized review of medical records. The stroke-free status of potentially discordant siblings is confirmed by validated structured telephone interview. Blood samples for DNA analysis are taken from concordant sibling pairs and, if applicable, from 1 discordant sibling. Epstein-Barr virus-transformed lymphoblastoid cell lines are created, and a scan of the human genome is planned. DISCUSSION: Conducting adequately powered genomics studies of stroke in humans is challenging because of the heterogeneity of the stroke phenotype and the difficulty of obtaining DNA samples from clinically well-characterized members of a cohort of stroke pedigrees. The multicentered design of this study is intended to efficiently assemble a cohort of ischemic stroke pedigrees without invoking community consent or using cold-calling of pedigree members.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.