ArticleAmerican journal of human genetics2002
Quantitative-trait homozygosity and association mapping and empirical genomewide significance in large, complex pedigrees: fasting serum-insulin level in the Hutterites.
Article in American journal of human genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
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Who cites it
75 citing papers in PubMed.
- JASPER: Fast, powerful, multitrait association testing in structured samples gives insight on pleiotropy in gene expression.American journal of human genetics · 2024Article
- JASPER: fast, powerful, multitrait association testing in structured samples gives insight on pleiotropy in gene expression.bioRxiv : the preprint server for biology · 2023Article
- BRASS: Permutation methods for binary traits in genetic association studies with structured samples.PLoS genetics · 2023Article
- Testing the accuracy of 3D automatic landmarking via genome-wide association studies.G3 (Bethesda, Md.) · 2022Article
- Pear genetics: Recent advances, new prospects, and a roadmap for the future.Horticulture research · 2022Article
- Article
- PolyQTL: Bayesian multiple eQTL detection with control for population structure and sample relatedness.Bioinformatics (Oxford, England) · 2019Article
- Association score testing for rare variants and binary traits in family data with shared controls.Briefings in bioinformatics · 2019Article
- Two-way mixed-effects methods for joint association analysis using both host and pathogen genomes.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- L-GATOR: Genetic Association Testing for a Longitudinally Measured Quantitative Trait in Samples with Related Individuals.American journal of human genetics · 2018Article
- Coping with family structure in genome-wide association studies: a comparative evaluation.BMC proceedings · 2018Article
- An Unbiased Estimator of Gene Diversity with Improved Variance for Samples Containing Related and Inbred Individuals of any Ploidy.G3 (Bethesda, Md.) · 2017Article
- CERAMIC: Case-Control Association Testing in Samples with Related Individuals, Based on Retrospective Mixed Model Analysis with Adjustment for Covariates.PLoS genetics · 2016Article
- G-STRATEGY: Optimal Selection of Individuals for Sequencing in Genetic Association Studies.Genetic epidemiology · 2016Article
- Integration of genome-wide association and extant brain expression QTL identifies candidate genes influencing prepulse inhibition in inbred F1 mice.Genes, brain, and behavior · 2016Article
- Mapping of Craniofacial Traits in Outbred Mice Identifies Major Developmental Genes Involved in Shape Determination.PLoS genetics · 2015Article
- Permutation testing in the presence of polygenic variation.Genetic epidemiology · 2015Article
- PRIMAL: Fast and accurate pedigree-based imputation from sequence data in a founder population.PLoS computational biology · 2015Article
- Statistical methods for genome-wide and sequencing association studies of complex traits in related samples.Current protocols in human genetics · 2015Review
- Review
15 more citing papers are in PubMed but not listed here.
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3 authors.
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Abstract
We present methods for linkage and association mapping of quantitative traits for a founder population with a large, known genealogy. We detect linkage to quantitative-trait loci (QTLs) through a multipoint homozygosity-mapping method. We propose two association methods, one of which is single point and uses a general two-allele model and the other of which is multipoint and uses homozygosity by descent for a particular allele. In all three methods, we make extensive use of the pedigree and genotype information, while keeping the computations simple and efficient. To assess significance, we have developed a permutation-based test that takes into account the covariance structure due to relatedness of individuals and can be used to determine empirical genomewide and locus-specific P values. In the case of multivariate-normally distributed trait data, the permutation-based test is asymptotically exact. The test is broadly applicable to a variety of mapping methods that fall within the class of linear statistical models (e.g., variance-component methods), under the assumption of random ascertainment with respect to the phenotype. For obtaining genomewide P values, our proposed method is appropriate when positions of markers are independent of the observed linkage signal, under the null hypothesis. We apply our methods to a genome screen for fasting insulin level in the Hutterites. We detect significant genomewide linkage on chromosome 19 and suggestive evidence of QTLs on chromosomes 1 and 16.
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