ArticleProceedings of the National Academy of Sciences of the United States of America2002
The organization of Physcomitrella patensRAD51 genes is unique among eukaryotic organisms.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 37 citations in OpenAlex.
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- The rDNA Loci-Intersections of Replication, Transcription, and Repair Pathways.International journal of molecular sciences · 2021Review
- The Importance of ATM and ATR inGenes · 2020Article
- Evolution of meiotic recombination genes in maize and teosinte.BMC genomics · 2017Article
- Gene Targeting Without DSB Induction Is Inefficient in Barley.Frontiers in plant science · 2016Article
- Horizontal transfer of bacterial polyphosphate kinases to eukaryotes: implications for the ice age and land colonisation.BMC research notes · 2013Article
- Article
- The RAD51 and DMC1 homoeologous genes of bread wheat: cloning, molecular characterization and expression analysis.BMC research notes · 2010Article
- Plant DNA recombinases: a long way to go.Journal of nucleic acids · 2010Article
- Homologous recombination properties of OsRad51, a recombinase from rice.Plant molecular biology · 2008Article
- Article
- Differential requirements for RAD51 in Physcomitrella patens and Arabidopsis thaliana development and DNA damage repair.The Plant cell · 2007Article
- TCP transcription factors predate the emergence of land plants.Journal of molecular evolution · 2007Article
- The chromatin assembly factor subunit FASCIATA1 is involved in homologous recombination in plants.The Plant cell · 2006Article
- The mechanism of gene targeting in Physcomitrella patens: homologous recombination, concatenation and multiple integration.Nucleic acids research · 2006Article
- Parameters determining the efficiency of gene targeting in the moss Physcomitrella patens.Nucleic acids research · 2005Article
- Enhancing gene targeting efficiency in higher plants: rice is on the move.Transgenic research · 2005Review
- A tool for understanding homologous recombination in plants.Plant cell reports · 2003Review
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetic recombination pathways and genes are well studied, but relatively little is known in plants, especially in lower plants. To study the recombination apparatus of a lower land plant, a recombination gene well characterized particularly in yeast, mouse, and man, the RAD51 gene, was isolated from the moss Physcomitrella patens and characterized. Two highly homologous RAD51 genes were found to be present. Duplicated RAD51 genes have been found thus far exclusively in eukaryotes with duplicated genomes. Therefore the presence of two highly homologous genes suggests a recent genome duplication event in the ancestry of Physcomitrella. Comparison of the protein sequences to Rad51 proteins from other organisms showed that both RAD51 genes originated within the group of plant Rad51 proteins. However, the two proteins form a separate clade in a phylogenetic tree of plant Rad51 proteins. In contrast to RAD51 genes from other multicellular eukaryotes, the Physcomitrella genes are not interrupted by introns. Because introns are a common feature of Physcomitrella genes, the lack of introns in the RAD51 genes is unusual and may indicate the presence of an unusual recombination apparatus in this organism. The presence of duplicated intronless RAD51 genes is unique among eukaryotes. Studies of further members of this lineage are needed to determine whether this feature may be typical of lower plants.
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