ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Extended plasticity of visual cortex in dark-reared animals may result from prolonged expression of cpg15-like genes.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- The Role of Neuritin 1 in Synaptic Plasticity and Sensory Nerve Function: Integrator of Neurotrophic, Metabolic and Injury Signals.The European journal of neuroscience · 2026Review
- Neuritin: a multifaceted neuroprotective factor with emerging applications for neurodegeneration.Frontiers in neuroscience · 2025Review
- Dendritic Spine Plasticity: Function and Mechanisms.Frontiers in synaptic neuroscience · 2020Article
- CPG15/Neuritin Mimics Experience in Selecting Excitatory Synapses for Stabilization by Facilitating PSD95 Recruitment.Cell reports · 2019Article
- Synaptic and circuit development of the primary sensory cortex.Experimental & molecular medicine · 2018Review
- Soluble cpg15 from Astrocytes Ameliorates Neurite Outgrowth Recovery of Hippocampal Neurons after Mouse Cerebral Ischemia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Neuritin Inhibits Notch Signaling through Interacted with Neuralized to Promote the Neurite Growth.Frontiers in molecular neuroscience · 2017Article
- Neurochemical changes in the pericalcarine cortex in congenital blindness attributable to bilateral anophthalmia.Journal of neurophysiology · 2015Article
- Neuritin 1 promotes retinal ganglion cell survival and axonal regeneration following optic nerve crush.Cell death & disease · 2015Article
- Neuritin can normalize neural deficits of Alzheimer's disease.Cell death & disease · 2014Article
- Molecular mechanisms of activity-dependent changes in dendritic morphology: role of RGK proteins.Trends in neurosciences · 2014Review
- Aberrant development and plasticity of excitatory visual cortical networks in the absence of cpg15.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- CPG15 regulates synapse stability in the developing and adult brain.Genes & development · 2011Article
- Activity-regulated genes as mediators of neural circuit plasticity.Progress in neurobiology · 2011Review
- The function of activity-regulated genes in the nervous system.Physiological reviews · 2009Review
- Developmental profile of tissue plasminogen activator in postnatal Long Evans rat visual cortex.Molecular vision · 2008Article
- Androgen regulates neuritin mRNA levels in an in vivo model of steroid-enhanced peripheral nerve regeneration.Journal of neurotrauma · 2008Article
- Androgen regulation of axon growth and neurite extension in motoneurons.Hormones and behavior · 2008Review
- cpg15 and cpg15-2 constitute a family of activity-regulated ligands expressed differentially in the nervous system to promote neurite growth and neuronal survival.The Journal of comparative neurology · 2008Article
- Bidirectional regulation of Munc13-3 protein expression by age and dark rearing during the critical period in mouse visual cortex.Neuroscience · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
cpg15 is an activity-regulated gene that encodes a membrane-bound ligand that coordinately regulates growth of apposing dendritic and axonal arbors and the maturation of their synapses. These properties make it an attractive candidate for participating in plasticity of the mammalian visual system. Here we compare cpg15 expression during normal development of the rat visual system with that seen in response to dark rearing, monocular blockade of retinal action potentials, or monocular deprivation. Our results show that the onset of cpg15 expression in the visual cortex is coincident with eye opening, and it increases until the peak of the critical period at postnatal day 28 (P28). This early expression is independent of both retinal activity and visual experience. After P28, a component of cpg15 expression in the visual cortex, lateral geniculate nucleus (LGN), and superior colliculus (SC) develops a progressively stronger dependence on retinally driven action potentials. Dark rearing does not affect cpg15 mRNA expression in the LGN and SC at any age, but it does significantly affect its expression in the visual cortex from the peak of the critical period and into adulthood. In dark-reared rats, the peak level of cpg15 expression in the visual cortex at P28 is lower than in controls. Rather than showing the normal decline with maturation, these levels are maintained in dark-reared animals. We suggest that the prolonged plasticity in the visual cortex that is seen in dark-reared animals may result from failure to downregulate genes such as cpg15 that could promote structural remodeling and synaptic maturation.
Indexed as
Identifiers
11880509PMC3062906What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.