ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Genetic dysmyelination alters the molecular architecture of the nodal region.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 101 citations in OpenAlex.
- Review
- c-Jun N-terminal kinase 1 (JNK1) modulates oligodendrocyte progenitor cell architecture, proliferation and myelination.Scientific reports · 2021Article
- Neuron-Oligodendrocyte Interactions in the Structure and Integrity of Axons.Frontiers in cell and developmental biology · 2021Review
- Altered Expression of Ion Channels in White Matter Lesions of Progressive Multiple Sclerosis: What Do We Know About Their Function?Frontiers in cellular neuroscience · 2021Review
- Nodes of Ranvier during development and repair in the CNS.Nature reviews. Neurology · 2020Review
- Review
- Loss of Saltation and Presynaptic Action Potential Failure in Demyelinated Axons.Frontiers in cellular neuroscience · 2017Article
- Postnatal Loss of Neuronal and Glial Neurofascins Differentially Affects Node of Ranvier Maintenance and Myelinated Axon Function.Frontiers in cellular neuroscience · 2017Article
- Functional and structural properties of ion channels at the nerve terminal depends on compact myelin.The Journal of physiology · 2016Article
- The axon-glia unit in white matter stroke: mechanisms of damage and recovery.Brain research · 2015Review
- Combination of electroacupuncture and grafted mesenchymal stem cells overexpressing TrkC improves remyelination and function in demyelinated spinal cord of rats.Scientific reports · 2015Article
- Demyelination in multiple sclerosis.Handbook of clinical neurology · 2014Review
- Neuro-glial interactions at the nodes of Ranvier: implication in health and diseases.Frontiers in cellular neuroscience · 2013Review
- Effects of adult neural precursor-derived myelination on axonal function in the perinatal congenitally dysmyelinated brain: optimizing time of intervention, developing accurate prediction models, and enhancing performance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Organization and maintenance of molecular domains in myelinated axons.Journal of neuroscience research · 2013Review
- Unmyelinated nerve fibers in the human dental pulp express markers for myelinated fibers and show sodium channel accumulations.BMC neuroscience · 2012Article
- Axon-glial interaction in the CNS: what we have learned from mouse models of Pelizaeus-Merzbacher disease.Journal of anatomy · 2011Review
- Myelination and axonal electrical activity modulate the distribution and motility of mitochondria at CNS nodes of Ranvier.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Article
- Endpoints in myelin-deficient (MD) rats.Comparative medicine · 2010Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 3 countries.
Funding
Abstract
We have examined the molecular organization of axons in the spinal cords of myelin-deficient (md) rats, which have profound CNS dysmyelination associated with oligodendrocyte cell death. Although myelin sheaths are rare, most large axons are at least partially surrounded by oligodendrocyte processes. At postnatal day 7 (P7), almost all node-like clusters of voltage-gated Na+ channels and ankyrinG are adjacent to axonal segments ensheathed by oligodendrocytes, but at P21, many node-like clusters are found in axonal segments that lack oligodendrocyte ensheathment. In P21 wild-type (WT) rats, the voltage-gated Na+ channels Na(v)1.2, Na(v)1.6, and Na(v)1.8, are found in different subpopulations of myelinated axons, and md rats have a similar distribution. The known molecular components of paranodes--contactin, Caspr, and neurofascin 155--are not clustered in md spinal cords, and no septate-like junctions between oligodendrocyte processes and axons are found by electron microscopy. Furthermore, Kv1.1 and Kv1.2 K+ channels are not spatially segregated from the node-like clusters of Na+ channels in md rats, in contrast to their WT littermates. These results suggest the following: node-like clusters of voltage-gated Na+ channels and ankyrinG form adjacent to ensheathed axonal segments even in the absence of a myelin sheath; these clusters persist after oligodendrocyte cell death; dysmyelination does not alter the expression of different nodal of voltage-gated Na+ channels; the absence of paranodes results in the mislocalization of neurofascin155, contactin, and Caspr, and the aberrant localization of Kv1.1 and Kv1.2.
Indexed as
Identifiers
11880502PMC6758867W2150584618What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.