ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Consequences of the stoichiometry of Slo1 alpha and auxiliary beta subunits on functional properties of large-conductance Ca2+-activated K+ channels.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
83 citing papers in PubMed, 129 citations in OpenAlex.
- Article
- β2 and β3a regulatory subunits can coassemble in the same BK channels.The Journal of general physiology · 2026Article
- Redox Regulation of KAntioxidants & redox signaling · 2024Review
- BK channels of five different subunit combinations underlie the de novo KCNMA1 G375R channelopathy.The Journal of general physiology · 2023Article
- CaInternational journal of molecular sciences · 2023Review
- Ion channels and channelopathies in glomeruli.Physiological reviews · 2023Review
- Mapping the functional expression of auxiliary subunits of KScientific reports · 2022Article
- The AMIGO1 adhesion protein activates Kv2.1 voltage sensors.Biophysical journal · 2022Article
- The LRRC family of BK channel regulatory subunits: potential roles in health and disease.The Journal of physiology · 2022Review
- Effect of an autism-associatedCurrent research in physiology · 2022Article
- State-dependent inhibition of BK channels by the opioid agonist loperamide.The Journal of general physiology · 2021Article
- Comparison of KHandbook of experimental pharmacology · 2021Article
- The Membrane Cholesterol Modulates the Interaction Between 17-βEstradiol and the BK Channel.Frontiers in pharmacology · 2021Article
- Diverse Mechanisms of Sound Frequency Discrimination in the Vertebrate Cochlea.Trends in neurosciences · 2020Review
- Molecular structures of the human Slo1 KeLife · 2019Article
- Rectification ratio based determination of disulfide bonds of β2 extracellular loop of BK channel.Channels (Austin, Tex.) · 2019Article
- Regulation of BK Channels by Beta and Gamma Subunits.Annual review of physiology · 2019Review
- Regulatory γ1 subunits defy symmetry in functional modulation of BK channels.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Calcium- and voltage-gated BK channels in vascular smooth muscle.Pflugers Archiv : European journal of physiology · 2018Review
- Impaired Trafficking of β1 Subunits Inhibits BK Channels in Cerebral Arteries of Hypertensive Rats.Hypertension (Dallas, Tex. : 1979) · 2018Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Auxiliary beta subunits play a major role in defining the functional properties of large-conductance, Ca2+-dependent BK-type K+ channels. In particular, both the beta1 and beta2 subunits produce strong shifts in the voltage dependence of channel activation at a given Ca2+. Beta subunits are thought to coassemble with alpha subunits in a 1:1 stoichiometry, such that a full ion channel complex may contain up to four beta subunits per channel. However, previous results raise the possibility that ion channels with less than a full complement of beta subunits may also occur. The functional consequence of channels with differing stoichiometries remains unknown. Here, using expression of alpha and beta subunits in Xenopus oocytes, we show explicitly that functional BK channels can arise with less than four beta subunits. Furthermore, the results show that, for both the beta1 and beta2 subunits, each individual beta subunit produces an essentially identical, incremental effect on the voltage dependence of gating. For channels arising from alpha + beta2 subunits, the number of beta2 subunits per channel also has a substantial impact on properties of steady-state inactivation and recovery from inactivation. Thus, the stoichiometry of alpha:beta subunit assembly can play a major functional role in defining the apparent Ca2+ dependence of activation of BK channels and in influencing the availability of BK channels for activation.
Indexed as
Identifiers
11880485PMC6758889W2139604481What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.