ArticleJournal of clinical microbiology2002
Rapid and sensitive detection of physical status of human papillomavirus type 16 DNA by quantitative real-time PCR.
Article in Journal of clinical microbiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Who cites it
23 citing papers in PubMed, 92 citations in OpenAlex.
- Detection of partial deletions of the human papillomavirus 16 E6 gene in a subset of oropharyngeal and cervical cancers.Virus research · 2025Article
- Evaluation of human papillomavirus type 16 viral load and genome physical status in Iranian women with cervical disease.Molecular biology reports · 2024Article
- Prognostic role of HPV integration status and molecular profile in advanced anal carcinoma: An ancillary study to the epitopes-HPV02 trial.Frontiers in oncology · 2022Article
- Prognostic significance of human papillomavirus 16 viral load level in patients with oropharyngeal cancer.Cancer science · 2021Article
- Human Papillomavirus Type 16 Integration Analysis by Real-time PCR Assay in Associated Cancers.Translational oncology · 2018Article
- A dualistic model of primary anal canal adenocarcinoma with distinct cellular origins, etiologies, inflammatory microenvironments and mutational signatures: implications for personalised medicine.British journal of cancer · 2018Article
- APOBEC3A associates with human papillomavirus genome integration in oropharyngeal cancers.Oncogene · 2017Article
- High Prevalence of Human Papillomavirus in Colorectal Cancer in Hispanics: A Case-Control Study.Gastroenterology research and practice · 2016Article
- Integration of human papillomavirus type 16 in cervical cancer cells.Open medicine (Warsaw, Poland) · 2015Article
- Tumourigenesis driven by the human papillomavirus type 16 Asian-American e6 variant in a three-dimensional keratinocyte model.PloS one · 2014Article
- Article
- Correlation between ebv co-infection and HPV16 genome integrity in Tunisian cervical cancer patients.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2012Article
- Oxidative stress in HPV-driven viral carcinogenesis: redox proteomics analysis of HPV-16 dysplastic and neoplastic tissues.PloS one · 2012Article
- Detection and quantitation of HPV in genital and oral tissues and fluids by real time PCR.Virology journal · 2010Article
- Sequence variation of human papillomavirus type 16 and measurement of viral integration by quantitative PCR.Journal of clinical microbiology · 2009Article
- The physical state of HPV16 infection and its clinical significance in cancer precursor lesion and cervical carcinoma.Journal of cancer research and clinical oncology · 2008Article
- Analysis of human papillomavirus type 16 (HPV16) DNA load and physical state for identification of HPV16-infected women with high-grade lesions or cervical carcinoma.Journal of clinical microbiology · 2008Article
- Critical evaluation of HPV16 gene copy number quantification by SYBR green PCR.BMC biotechnology · 2008Article
- Use of multiple displacement amplification in the investigation of human papillomavirus physical status.Journal of clinical pathology · 2007Article
- Human papillomavirus type 16 integration in cervical carcinoma in situ and in invasive cervical cancer.Journal of clinical microbiology · 2006Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A rapid quantitative real-time PCR method was employed to quantify the copy number of E2 and E6 genes for analysis of the physical status of human papillomavirus type 16 (HPV-16) DNA. Significant differences with respect to both copy numbers were found when more than 40% of HPV-16 DNA was integrated with disruption of the E2 gene in an experimental model. The physical status of HPV-16 DNA in 50 clinical samples was exclusively episomal in 21 cases (42%), concomitant in 14 cases (28%), and integrated in 15 cases (30%). The prevalence of integrated and/or concomitant forms of HPV-16 DNA increased with progression of cervical disease. Four of 11 cervical intraepithelial neoplasia involved integrated forms of HPV-16 DNA partially or exclusively. This rapid, sensitive technique is useful in the analysis of the physical status of HPV DNA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.