ArticleJournal of clinical microbiology2002
Ca3 fingerprinting of Candida albicans isolates from human immunodeficiency virus-positive and healthy individuals reveals a new clade in South Africa.
Article in Journal of clinical microbiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 92 citations in OpenAlex.
- Article
- Candida albicans selection for human commensalism results in substantial within-host diversity without decreasing fitness for invasive disease.PLoS biology · 2023Article
- Mechanisms of genome evolution in Candida albicans.Current opinion in microbiology · 2019Review
- Gene flow contributes to diversification of the major fungal pathogen Candida albicans.Nature communications · 2018Article
- Real-Time Imaging of the Azole Class of Antifungal Drugs in Live Candida Cells.ACS chemical biology · 2017Article
- A modular yeast biosensor for low-cost point-of-care pathogen detection.Science advances · 2017Article
- Article
- Molecular and Histological Association Between Candida albicans from Oral Soft Tissue and Carious Dentine of HIV-Positive Children.Mycopathologia · 2015Article
- Genetic and phenotypic intra-species variation in Candida albicans.Genome research · 2015Article
- How often do they have sex? A comparative analysis of the population structure of seven eukaryotic microbial pathogens.PloS one · 2014Article
- Typing Candida albicans oral isolates from healthy brazilian schoolchildren using multilocus enzyme electrophoresis reveals two highly polymorphic taxa.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2011Article
- ALS51, a newly discovered gene in the Candida albicans ALS family, created by intergenic recombination: analysis of the gene and protein, and implications for evolution of microbial gene families.FEMS immunology and medical microbiology · 2011Article
- Candida albicans: genotyping methods and clade related phenotypic characteristics.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2010Article
- Candidemia surveillance in Brazil: evidence for a geographical boundary defining an area exhibiting an abatement of infections by Candida albicans group 2 strains.Journal of clinical microbiology · 2010Article
- Monoclonal antibodies specific for Candida albicans Als3 that immunolabel fungal cells in vitro and in vivo and block adhesion to host surfaces.Journal of microbiological methods · 2009Article
- Property differences among the four major Candida albicans strain clades.Eukaryotic cell · 2009Article
- The white cell response to pheromone is a general characteristic of Candida albicans strains.Eukaryotic cell · 2009Article
- Mating is rare within as well as between clades of the human pathogen Candida albicans.Fungal genetics and biology : FG & B · 2008Article
- Candidemia and candiduria in critically ill patients admitted to intensive care units in France: incidence, molecular diversity, management and outcome.Intensive care medicine · 2008Article
- Multilocus sequence typing reveals that the population structure of Candida dubliniensis is significantly less divergent than that of Candida albicans.Journal of clinical microbiology · 2008Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
To examine the question of strain specificity in oropharyngeal candidiasis associated with human immunodeficiency virus (HIV) infection, oral samples were collected from 1,196 HIV-positive black South Africans visiting three clinics and 249 Candida albicans isolates were selected for DNA fingerprinting with the complex DNA fingerprinting probe Ca3. A total of 66 C. albicans isolates from healthy black South Africans and 46 from healthy white South Africans were also DNA fingerprinted as controls. Using DENDRON software, a cluster analysis was performed and the identified groups were compared to a test set of isolates from the United States in which three genetic groups (I, II, and III) were previously identified by a variety of genetic fingerprinting methods. All of the characterized South African collections (three from HIV-positive black persons, two from healthy black persons, and one from healthy white persons) included group I, II, and III isolates. In addition, all South African collections included a fourth group (group SA) completely absent in the U.S. collection. The proportion of group SA isolates in HIV-positive and healthy black South Africans was 53% in both cases. The proportion in healthy white South Africans was 33%. In a comparison of HIV-positive patients with and without oropharyngeal symptoms of infection, the same proportions of group I, II, III, and SA isolates were obtained, indicating no shift to a particular group on infection. However, by virtue of its predominance as a commensal and in infections, group SA must be considered the most successful in South Africa. Why group SA isolates represent 53 and 33% of colonizing strains in black and white South Africans and are absent in the U.S. collection represents an interesting epidemiological question.
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