ArticleArthritis research2002
Th1 and Th2 cytokines regulate proteoglycan-specific autoantibody isotypes and arthritis.
Article in Arthritis research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 2 citations in OpenAlex.
- Aggrecan and polymeric immunoglobulin receptor in extracellular vesicles of patients with seropositive rheumatoid arthritis.Journal of translational autoimmunity · 2026Article
- Murine and Humanized Mouse Models in Autoimmune Disease Research and Therapeutics Development.Biology · 2026Review
- Evaluation of the Synergistic Effects of Mineral and Postbiotics Mixtures in Ameliorating Atopic Dermatitis in the NC/Nga Mouse Model.Journal of microbiology and biotechnology · 2026Article
- The immunological and pharmacokinetic evaluation of Lipid-PLGA hybrid nanoparticle-based oxycodone vaccines.Biomaterials · 2025Article
- A self-adjuvanted VLPs-based Covid-19 vaccine proven versatile, safe, and highly protective.Scientific reports · 2024Article
- NKT cells promote Th1 immune bias to dengue virus that governs long-term protective antibody dynamics.The Journal of clinical investigation · 2024Article
- Splenectomy at early stage of autoimmune arthritis delayed inflammatory response and reduced joint deterioration in mice.Clinical and experimental immunology · 2024Article
- Comparative Evaluation of Recombinant and Acellular Pertussis Vaccines in a Murine Model.Vaccines · 2024Article
- The use of animal models in rheumatoid arthritis research.Journal of Yeungnam medical science · 2023Article
- Splenectomy modulates the immune response but does not prevent joint inflammation in a mouse model of RA.Clinical and experimental immunology · 2022Article
- Humulus japonicus extract ameliorates collagen‑induced arthritis in mice through regulation of overall articular inflammation.International journal of molecular medicine · 2020Article
- Sex-dependent effects of bisphenol A on type 1 diabetes development in non-obese diabetic (NOD) mice.Archives of toxicology · 2019Article
- Antibody immunoglobulin G1 and immunoglobulin G2a responses against some cystic fluid proteins ofVeterinary world · 2018Article
- 3,5-Di-C-β-D-glucopyranosyl phloroacetophenone, a major component of Melicope ptelefolia, suppresses fibroblast activation and alleviates arthritis in a mouse model: Potential therapeutics for rheumatoid arthritis.International journal of molecular medicine · 2018Article
- Intradermal active full-length DNA Aβ42 immunization via electroporation leads to high anti-Aβ antibody levels in wild-type mice.Journal of neuroimmunology · 2018Article
- A Dual-Type L2 11-88 Peptide from HPV Types 16/18 Formulated in Montanide ISA 720 Induced Strong and Balanced Th1/Th2 Immune Responses, Associated with High Titers of Broad Spectrum Cross-Reactive Antibodies in Vaccinated Mice.Journal of immunology research · 2018Article
- Mouse immune thrombocytopenia is associated with Th1 bias and expression of activating Fcγ receptors.International journal of hematology · 2017Article
- Article
- Peripheral Ulcerative Keratitis Associated with Autoimmune Disease: Pathogenesis and Treatment.Journal of ophthalmology · 2017Review
- Of mice and men: how animal models advance our understanding of T-cell function in RA.Nature reviews. Rheumatology · 2014Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
BALB/c mice immunized with human cartilage proteoglycan (PG) develop arthritis accompanied by the production of autoantibodies to mouse cartilage PG. To determine whether the autoantibody isotype contributes to the onset and severity of arthritis, PG-specific serum IgG1 (Th2, IL-4-cytokine-supporting) and IgG2a (Th1, IFN-gamma-controlling) concentrations were monitored during immunization with PG in IL-4-deficient and IFN-gamma-deficient mice. Paradoxically, despite elevated IFN-gamma, the PG-specific IgG1 isotype was significantly higher than the PG-specific IgG2a response, and the PG-specific IgG1 isotype was independent of IL-4. In contrast, the serum concentration of PG-specific IgG2a isotype was six times higher in IL-4-deficient mice than in wild-type controls. Moreover, the high concentration of PG-specific IgG2a isotype in IL-4-deficient mice corresponded to an increased severity of arthritis. The concentration of PG-specific IgG2a isotype was lower in IFN-gamma-deficient mice than in wild-type mice, and the incidence and severity of arthritis also were significantly lower. Concentrations of PG-specific IgG2a isotype autoantibody correlated with the onset and severity of arthritis, suggesting a pathological role of this isotype, probably locally in the joint.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.