ArticleClinical and experimental immunology2002
Interleukin-1 receptor antagonist gene polymorphism and mortality in patients with severe sepsis.
Article in Clinical and experimental immunology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00732277 (Evaluation of Corticosteroid Therapy in Childhood Severe Sepsis), which is not on this map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Corticosteroid Therapy in Childhood Severe Sepsis (Steroids in Paediatric Sepsis, StePS) - a Randomised Pilot Study
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 122 citations in OpenAlex.
- Associations between interleukin-1 gene polymorphisms and sepsis risk: a meta-analysis.BMC medical genetics · 2014Pooled it
- A functional synonymous coding variant in the IL1RN gene is associated with survival in septic shock.American journal of respiratory and critical care medicine · 2014Trial
- Association of Interleukin-1 Receptor Antagonist (Global medical genetics · 2023Article
- COVID-19 Disease and Associated Thrombocytopenia: Pathogenesis and a Clue to the Etiology.Diagnostics (Basel, Switzerland) · 2022Article
- The rs8506 TT Genotype inFrontiers in public health · 2022Article
- Genetic Sequence Variants inChildren (Basel, Switzerland) · 2020Article
- Review
- Cytokine storm and sepsis disease pathogenesis.Seminars in immunopathology · 2017Review
- Loss of Interleukin 1 Receptor Antagonist Enhances Susceptibility to Ebola Virus Infection.The Journal of infectious diseases · 2015Article
- Pathophysiology of sepsis-related cardiac dysfunction: driven by inflammation, energy mismanagement, or both?Current heart failure reports · 2015Review
- The Value of Admission Serum IL-8 Monitoring and the Correlation with IL-8 (-251A/T) Polymorphism in Critically Ill Patients.ISRN inflammation · 2014Article
- IL1RN coding variant is associated with lower risk of acute respiratory distress syndrome and increased plasma IL-1 receptor antagonist.American journal of respiratory and critical care medicine · 2013Article
- Delayed resolution of lung inflammation in Il-1rn-/- mice reflects elevated IL-17A/granulocyte colony-stimulating factor expression.American journal of respiratory cell and molecular biology · 2012Article
- Type 2 diabetes mellitus is associated with impaired cytokine response and adhesion molecule expression in human endotoxemia.Intensive care medicine · 2010Article
- Ethical considerations in the collection of genetic data from critically ill patients: what do published studies reveal about potential directions for empirical ethics research?The pharmacogenomics journal · 2010Article
- Genotypes coding for low serum levels of mannose-binding lectin are underrepresented among individuals suffering from noninfectious systemic inflammatory response syndrome.Clinical and vaccine immunology : CVI · 2010Article
- Genetic polymorphisms and posttraumatic complications.Comparative and functional genomics · 2010Article
- Association of mannose-binding lectin-2 genotype and serum levels with prognosis of sepsis.Critical care (London, England) · 2009Article
- Variation in the TLR4 gene influences the risk of organ failure and shock posttrauma: a cohort study.The Journal of trauma · 2009Article
- Interleukin-1 receptor antagonist intron 2 variable number of tandem repeats polymorphism and respiratory failure in children with community-acquired pneumonia.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2008Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aims to determine the influence of the polymorphism within the intron 2 of the interleukin-1 receptor antagonist gene (IL-1RN*) on the outcome of severe sepsis, and to assess its functional significance by correlating this polymorphism with the total production of interleukin-1 receptor antagonist (IL-1Ra) protein determined in stimulated peripheral blood mononuclear cells (PBMC). A group of 78 patients with severe sepsis (51 survivors and 27 nonsurvivors) was compared with a healthy control group of 130 blood donors, and 56 patients with uncomplicated pneumonia. We found a significant association between IL-1RN* polymorphism and survival. Thus, after adjusting for age and APACHE II score, multiple logistic regression analysis showed that patients homozygotes for the allele *2 had a 6.47-fold increased risk of death (95% CI 1.01--41.47, P = 0.04). Besides, compared with patients homozygous or heterozygous for the allele *1, IL-1RN*2 homozygotes produced significantly lower levels of IL-1Ra from their PBMC. Our results suggest that insufficient production of this cytokine might contribute, among other factors, to the higher mortality rate found in severe sepsis patients with the IL-1RN*2 homozygous genotype.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.