Evidence map›Paper›PMID 11876745›Full record

ArticleClinical and experimental immunology2002

Transfection of single-stranded hepatitis A virus RNA activates MHC class I pathway.

K Suzuki, M Yanagi, A Mori-Aoki, E Moriyama, K J Ishii, L D Kohn

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and experimental immunology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. JAK kinases are required for the bacterial RNA and poly I:C induced tyrosine phosphorylation of PKR.International journal of clinical and experimental medicine · 2013
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

K SuzukiCell Regulation Section, Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Maryland, USA. koichis@nih.go.jp
M Yanagi
A Mori-Aoki
E Moriyama
K J Ishii
L D Kohn
National Institutes of Health · USCenter for Biologics Evaluation and Research · USKanazawa University · JPNational Institute of Diabetes and Digestive and Kidney Diseases · USNational Institute of Infectious Diseases · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although infection of single-stranded RNA viruses can enhance expression of major histocompatibility complex (MHC) class I genes, the mechanism underlying this process remains unclear. Recent studies have indicated that exposure of non-immune cells to double-stranded deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) of viral origin can directly increase the expression of MHC class I and related molecules without immune cell interaction. In this report, we show that transfection of single-stranded hepatitis A virus RNA into cultured hepatocytes results in the induction of genes for MHC class I, LMP2 and transporter for antigen processing (TAP1), in addition to the generation of viral proteins. We suggest that this stimulatory effect is due to the double-stranded RNA formed during replication of single-stranded viral RNA, and involves both double-stranded, RNA-dependent protein kinase PKR and the secretion of IFNbeta.

Indexed as

Gene Expression Regulation, ViralGenes, MHC Class II-kappa B ProteinsATP-Binding Cassette TransportersATP Binding Cassette Transporter, Subfamily B, Member 2Cells, CulturedDNA-Binding ProteinseIF-2 KinaseHepatitis A virusHepatoblastomaHepatocytesHistocompatibility Antigens Class IHumansInterferon-betaLiver NeoplasmsNeoplasm ProteinsATP-Binding Cassette TransportersATP Binding Cassette Transporter, Subfamily B, Member 2DNA-Binding ProteinsEBV-associated membrane antigen, Epstein-Barr viruseIF-2 KinaseHistocompatibility Antigens Class II kappa B beta proteinI-kappa B ProteinsInterferon-betaNeoplasm ProteinsNF-kappa BRNA, Double-StrandedRNA, MessengerRNA, ViralTAP1 protein, humanViral Matrix ProteinsViral Proteins

Identifiers

PMID11876745
PMCPMC1906343
OpenAlexW2091359174

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.