ReviewMicrobiology and molecular biology reviews : MMBR2002
Regulation of cellular differentiation in filamentous cyanobacteria in free-living and plant-associated symbiotic growth states.
Review in Microbiology and molecular biology reviews : MMBR, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
131 citing papers in PubMed, 416 citations in OpenAlex.
- Metagenome-assembled genomes for NMicrobiology resource announcements · 2026Article
- Filamentous Algae for Wastewater Circularity: A Review of Wastewater Treatment, Resource Recovery, and Biorefinery Opportunities.Microorganisms · 2026Review
- The limits of information in precise regulation of early multicellular life cycles.bioRxiv : the preprint server for biology · 2026Article
- Mutual interference of phosphorus starvation and diazotrophy in the cyanobacteria Nostoc sp. PCC 7120.Protoplasma · 2026Article
- Predicting FOX gene candidates for oxic nitrogen fixation using multi-omic machine learning and comparative bioinformatics.Scientific reports · 2026Article
- Green genes from blue greens: challenges and solutions to unlocking the potential of cyanobacteria in drug discovery.Natural product reports · 2026Review
- Genomes of NBMC genomics · 2026Article
- Article
- Microbial responses under sunlight-dark conditions accelerate sequestration and transformation of soil biogenic, redox and non-redox components, including As and Hg.Scientific reports · 2025Article
- Quantitative assessment of hormogonia induction in Nostoc punctiforme by a fluorescent reporter strain.Journal of experimental botany · 2025Article
- Competition and interdependence define interactions of Nostoc sp. and Agrobacterium sp. under inorganic carbon limitation.NPJ biofilms and microbiomes · 2025Article
- EXCRETE workflow enables deep proteomics of the microbial extracellular environment.Communications biology · 2024Article
- The role of FraI in cell-cell communication and differentiation in the hormogonia-forming cyanobacteriummSphere · 2024Article
- Investigate Freshwater Algae Extract's Efficacy in Treating Diabetes Ulcers and Its Anti-Staphylococcal Properties.Reports of biochemistry & molecular biology · 2024Article
- Analysis of fate determination of vegetative cells with reduced phycocyanin content in a multicellular cyanobacterium using Raman microscopy.microPublication biology · 2024Article
- Symbiosis between cyanobacteria and plants: from molecular studies to agronomic applications.Journal of experimental botany · 2023Review
- Article
- Raman spectral analysis of microbial pigment compositions in vegetative cells and heterocysts of multicellular cyanobacterium.Biochemistry and biophysics reports · 2023Article
- Position-dependent changes in phycobilisome abundance in multicellular cyanobacterial filaments revealed by Raman spectral analysis.microPublication biology · 2023Article
- What can hornworts teach us?Frontiers in plant science · 2023Review
71 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Certain filamentous nitrogen-fixing cyanobacteria generate signals that direct their own multicellular development. They also respond to signals from plants that initiate or modulate differentiation, leading to the establishment of a symbiotic association. An objective of this review is to describe the mechanisms by which free-living cyanobacteria regulate their development and then to consider how plants may exploit cyanobacterial physiology to achieve stable symbioses. Cyanobacteria that are capable of forming plant symbioses can differentiate into motile filaments called hormogonia and into specialized nitrogen-fixing cells called heterocysts. Plant signals exert both positive and negative regulatory control on hormogonium differentiation. Heterocyst differentiation is a highly regulated process, resulting in a regularly spaced pattern of heterocysts in the filament. The evidence is most consistent with the pattern arising in two stages. First, nitrogen limitation triggers a nonrandomly spaced cluster of cells (perhaps at a critical stage of their cell cycle) to initiate differentiation. Interactions between an inhibitory peptide exported by the differentiating cells and an activator protein within them causes one cell within each cluster to fully differentiate, yielding a single mature heterocyst. In symbiosis with plants, heterocyst frequencies are increased 3- to 10-fold because, we propose, either differentiation is initiated at an increased number of sites or resolution of differentiating clusters is incomplete. The physiology of symbiotically associated cyanobacteria raises the prospect that heterocyst differentiation proceeds independently of the nitrogen status of a cell and depends instead on signals produced by the plant partner.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.