ArticleClinical and diagnostic laboratory immunology2002
Sodium bicarbonate enhances the severity of infection in neutropenic mice orally inoculated with Listeria monocytogenes EGD.
Article in Clinical and diagnostic laboratory immunology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 26 citations in OpenAlex.
- Article
- Host gastric corpus microenvironment facilitates Ascaris suum larval hatching and infection in a murine model.PLoS neglected tropical diseases · 2024Article
- Article
- The Phylogeny and Biological Function of Gastric Juice-Microbiological Consequences of Removing Gastric Acid.International journal of molecular sciences · 2019Review
- Animal models for oral transmission of Listeria monocytogenes.Frontiers in cellular and infection microbiology · 2014Review
- The aryl hydrocarbon receptor is required for optimal resistance to Listeria monocytogenes infection in mice.Journal of immunology (Baltimore, Md. : 1950) · 2007Article
- Surviving the acid test: responses of gram-positive bacteria to low pH.Microbiology and molecular biology reviews : MMBR · 2003Review
- Ability of the Listeria monocytogenes strain Scott A to cause systemic infection in mice infected by the intragastric route.Applied and environmental microbiology · 2002Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Epidemiological studies have suggested an association between antacid therapy and development of listeriosis in humans. In this study we used a neutropenic mouse model to demonstrate that oral administration of sodium bicarbonate shortly before intragastric (i.g.) inoculation with Listeria monocytogenes EGD (serotype 1/2a) significantly increased the severity of the resulting systemic infection. An explanation for this observation is provided by evidence that L. monocytogenes EGD is rapidly inactivated in synthetic gastric fluid at pH below 5. A second strain of L. monocytogenes (CM [serotype 1/2b]) exhibited little ability to cause systemic infection following i.g. inoculation and was not significantly enhanced by administration of sodium bicarbonate. Strain CM was readily inactivated in synthetic gastric fluid even at pH 7. These data suggest that gastric acidity and enzymes provide some innate defense against gastrointestinal listeriosis in neutropenic mice.
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