ArticleClinical and diagnostic laboratory immunology2002
Interpretation of the gamma interferon test for diagnosis of subclinical paratuberculosis in cattle.
Article in Clinical and diagnostic laboratory immunology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Lining the small intestine with mycobacteriophages protects fromProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Interferon-gamma producing CD4Veterinary research · 2024Article
- Evaluation of the performance of the IFN-γ release assay in bovine tuberculosis free herds from five European countries.Veterinary research · 2023Article
- Peripheral IFN-ɣ Production after Blood Stimulation with Different Mycobacterial Antigens in Goats Vaccinated against Paratuberculosis.Vaccines · 2022Article
- Mycobacterium avium subspecies paratuberculosis infection in cattle - a review in the context of seasonal pasture-based dairy herds.Irish veterinary journal · 2022Review
- Metabolomic changes in Mycobacterium avium subsp. paratuberculosis (MAP) challenged Holstein-Friesian cattle highlight the role of serum amino acids as indicators of immune system activation.Metabolomics : Official journal of the Metabolomic Society · 2022Article
- Johne's Disease in Dairy Cattle: An Immunogenetic Perspective.Frontiers in veterinary science · 2021Review
- Development and Validation of a Novel ELISA for the Specific Detection of Antibodies againstVeterinary medicine international · 2021Article
- Early Detection ofFrontiers in veterinary science · 2021Article
- Spectroscopic Characterization of Bovine, Avian and Johnin Purified Protein Derivative (PPD) with High-Throughput Fourier Transform InfraRed-Based Method.Pathogens (Basel, Switzerland) · 2019Article
- Characterization of the bovine salivary gland transcriptome associated with Mycobacterium avium subsp. paratuberculosis experimental challenge.BMC genomics · 2019Article
- Fecal shedding and tissue infections demonstrate transmission of Mycobacterium avium subsp. paratuberculosis in group-housed dairy calves.Veterinary research · 2017Article
- PCR Inhibition of a Quantitative PCR for Detection ofFrontiers in microbiology · 2017Article
- Bovine Immunoinhibitory Receptors Contribute to Suppression of Mycobacterium avium subsp. paratuberculosis-Specific T-Cell Responses.Infection and immunity · 2016Article
- Novel Cell Preservation Technique to Extend Bovine In Vitro White Blood Cell Viability.PloS one · 2015Article
- Lymphoproliferative and gamma interferon responses to stress-regulated Mycobacterium avium subsp. paratuberculosis recombinant proteins.Clinical and vaccine immunology : CVI · 2014Article
- Antemortem and postmortem examinations of the cattle calf naturally infected with Mycobacterium avium subsp. paratuberculosis.European journal of microbiology & immunology · 2013Article
- Production and proteomic characterisation of purified protein derivative from Mycobacterium avium subsp. paratuberculosis.Proteome science · 2012Article
- Indoleamine 2,3-dioxygenase, tryptophan catabolism, and Mycobacterium avium subsp. paratuberculosis: a model for chronic mycobacterial infections.Infection and immunity · 2011Article
- Genetic analysis of Mycobacterium avium complex strains used for producing purified protein derivatives.Clinical and vaccine immunology : CVI · 2006Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A group of 252 cattle without clinical signs of paratuberculosis (paraTB) in 10 herds infected with paraTB and a group of 117 cattle in 5 herds without paraTB were selected. Whole-blood samples were stimulated with bovine, avian, and johnin purified protein derivative (PPD) and examined for gamma interferon (IFN-gamma) release. For diagnosis of paraTB, satisfactory estimated specificities (95 to 99%) could be obtained by johnin PPD stimulation irrespective of interpretation relative to bovine PPD or no-antigen stimulation alone, but numbers of test positives in the infected herds varied from 64 to 112 with different interpretation criteria. For a limited number of test-positive animals, no change in the test results could be observed with increasing antigen concentrations but IFN-gamma responses were significantly reduced (P < 0.0001) and four out of seven reactors tested negative when stimulation was performed on day-old samples. Denmark is free of bovine tuberculosis, but cross-reactivity with paraTB could be documented for cattle more than 14 months old in paraTB-infected herds compared with those in non-paraTB-infected herds. In both paraTB-free and paraTB-infected herds, false positives were observed when the test was applied to calves less than 15 months of age. Until novel antigen formulations more specific for these diseases are available, interpretation of the IFN-gamma test must be individually adjusted to fit specific needs and the context within which the test is applied and, for paraTB, the test seems most appropriate for use as a supportive tool for evaluation of disease-preventive measures in young stock.
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