ArticleClinical and diagnostic laboratory immunology2002
Cell-associated interleukin-8 in cord blood of term and preterm infants.
Article in Clinical and diagnostic laboratory immunology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 24 citations in OpenAlex.
- Time course of endothelial damage in septic shock: prediction of outcome.Critical care (London, England) · 2005Trial
- Serum Biomarkers in Patent Ductus Arteriosus in Preterm Infants: A Narrative Review.Biomedicines · 2025Review
- Neonatal sepsis and inflammatory mediators.Mediators of inflammation · 2014Review
- Umbilical blood biomarkers for predicting early-onset neonatal sepsis.World journal of pediatrics : WJP · 2012Review
- Influence of Gestational Age, Cesarean Section and Hematocrit on lnterleukin-8 Concentrations in Plasma and Detergent-Lysed Whole Blood of Noninfected Newborns.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2011Article
- OX40 induces CCL20 expression in the context of antigen stimulation: an expanding role of co-stimulatory molecules in chemotaxis.Cytokine · 2010Article
- Lipopolysaccharide binding protein in preterm infants.Archives of disease in childhood. Fetal and neonatal edition · 2004Article
- Rapid simultaneous measurement of multiple cytokines using 100 microl sample volumes--association with neonatal sepsis.Clinical and experimental immunology · 2004Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To assess the effect of gestational age and labor on the interleukin-8 (IL-8) concentration in whole cord blood and serum, IL-8 levels were determined simultaneously in cord blood serum and lysate in 134 infants. Following the elimination of some of the samples due to exclusion criteria, the data for 99 uninfected infants (71 term and 28 preterm) and 9 infants with neonatal bacterial infection delivered either vaginally or by elective or emergency cesarean section were analyzed. The effects of labor and gestational age were tested by analysis of variance. IL-8 was not detectable in the serum of 25 infants, whereas IL-8 levels in whole blood were measurable in all of the samples. The median IL-8 conncentrations in whole cord blood lysate were 106 pg/ml (range, 20 to 415 pg/ml) in preterm infants and 176 pg/ml (range, 34 to 1,667 pg/ml) in term infants. In contrast to the IL-8 levels in serum, IL-8 levels in whole blood were reduced after ECS. Gestational age had no independent effect on the IL-8 concentrations in either serum or whole blood; these concentrations increased in infected infants after labor. We conclude that the neonatal proinflammatory response to labor stress was more evident in the concentrations of IL-8 in whole blood than in serum. The levels of IL-8 in whole-blood lysate reflect proinflammatory stimulation in neonates and may be a useful diagnostic tool for the early diagnosis of neonatal infection.
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