Evidence map›Paper›PMID 11872734›Full record

ArticleJournal of bacteriology2002

Lack of regulation of the modification-dependent restriction enzyme McrBC in Escherichia coli.

Mark Murphy, Stefanie Schmid Nuoffer, Thomas A Bickle

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bacteriology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mark MurphyDivision of Molecular Microbiology, Biozentrum of the University of Basel, CH-4056 Basel, Switzerland.
Stefanie Schmid Nuoffer
Thomas A Bickle

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Restriction alleviation (RA) by the type I restriction enzyme EcoKI is caused by treatments that damage DNA. RA is due to proteolysis of the EcoKI HsdR subunit by the ClpXP ATP-dependent protease. Here we show that the modification-dependent enzyme McrBC is not subject to RA, although it is moderately sensitive to ClpAP.

Indexed as

Escherichia coli ProteinsGene Expression Regulation, Bacterial2-AminopurineCalcium-Binding ProteinsDNA Restriction EnzymesEscherichia coliMutagenesis2-AminopurineCalcium-Binding ProteinsDNA Restriction EnzymesEscherichia coli ProteinsmcrB protein, E coli

Identifiers

PMID11872734
PMCPMC134900

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.