ArticleJournal of bacteriology2002
An extracellular matrix-associated zinc metalloprotease is required for dilauroyl phosphatidylethanolamine chemotactic excitation in Myxococcus xanthus.
Article in Journal of bacteriology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 62 citations in OpenAlex.
- Mycobacterium tuberculosis Zinc Metalloprotease-1 Assists Mycobacterial Dissemination in Zebrafish.Frontiers in microbiology · 2016Article
- Myxobacteria: Moving, Killing, Feeding, and Surviving Together.Frontiers in microbiology · 2016Review
- Reprolysin metalloproteases from Ixodes persulcatus, Rhipicephalus sanguineus and Rhipicephalus microplus ticks.Experimental & applied acarology · 2014Article
- Interaction between extracellular lipase LipA and the polysaccharide alginate of Pseudomonas aeruginosa.BMC microbiology · 2013Article
- MasABK proteins interact with proteins of the type IV pilin system to affect social motility of Myxococcus xanthus.PloS one · 2013Article
- The orphan histidine protein kinase SgmT is a c-di-GMP receptor and regulates composition of the extracellular matrix together with the orphan DNA binding response regulator DigR in Myxococcus xanthus.Molecular microbiology · 2012Article
- Myxococcus xanthus swarms are driven by growth and regulated by a pacemaker.Journal of bacteriology · 2011Article
- Statistical image analysis reveals features affecting fates of Myxococcus xanthus developmental aggregates.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
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- Natural variation in developmental life-history traits of the bacterium Myxococcus xanthus.FEMS microbiology ecology · 2010Article
- Gliding motility revisited: how do the myxobacteria move without flagella?Microbiology and molecular biology reviews : MMBR · 2010Review
- Social conflict in centimeter-and global-scale populations of the bacterium Myxococcus xanthus.Current biology : CB · 2009Article
- Structural organization of precursors of thermolysin-like proteinases.The protein journal · 2008Article
- Independence and interdependence of Dif and Frz chemosensory pathways in Myxococcus xanthus chemotaxis.Molecular microbiology · 2008Article
- Wound angiogenesis as a function of tissue oxygen tension: a mathematical model.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Spatial organization of Myxococcus xanthus during fruiting body formation.Journal of bacteriology · 2007Article
- Proteins associated with the Myxococcus xanthus extracellular matrix.Journal of bacteriology · 2007Article
- The orphan response regulator DigR is required for synthesis of extracellular matrix fibrils in Myxococcus xanthus.Journal of bacteriology · 2006Article
- Cohesion-defective mutants of Myxococcus xanthus.Journal of bacteriology · 2006Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An extracellular matrix connects bacteria that live in organized assemblages called biofilms. While the role of the matrix in the regulation of cell behavior has not been extensively examined in bacteria, we suggest that, like mammalian cells, the matrix facilitates cell-cell interactions involved with regulation of cohesion, motility, and sensory transduction. The extracellular matrix of the soil bacterium Myxococcus xanthus is essential for biofilm formation and fruiting body development. The matrix material is extruded as long, thin fibrils that mediate adhesion to surfaces, cohesion to other cells, and excitation by the chemoattractant dilauroyl phosphatidylethanolamine. We report the identification of a putative matrix-associated zinc metalloprotease called FibA (fibril protein A). Western blotting with FibA-specific monoclonal antibody 2105 suggests extensive proteolytic processing of FibA during assembly into fibrils, consistent with the autoprocessing observed with other members of the M4 metalloprotease family. Disruption of fibA had no obvious effect on the structure of the fibrils and did not inhibit cell cohesion, excitation by dioleoyl phosphatidylethanolamine, or activity of the A- or S-motility motors. However, the cells lost the ability to respond to dilauroyl phosphatidylethanolamine and to form well-spaced fruiting bodies, though substantial aggregation was observed. Chemotactic excitation of the fibA mutant was restored by incubation with purified wild-type fibrils. The results suggest that this metalloprotease is involved in sensory transduction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.