ReviewImmunology2002
Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases.
Review in Immunology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 149 citations in OpenAlex.
- HIV-1 envelope glycoprotein modulates CXCR4 clustering and dynamics on the T cell membrane.eLife · 2026Article
- Chemokines as regulators of CAR-T cell trafficking, function, and context-dependent tumor cell death.Frontiers in immunology · 2026Review
- Major pathophysiological changes in pulmonary disease provided a molecular insight based on deep learning approach.Scientific reports · 2025Article
- Predictive, preventive, and personalized medicine in breast cancer: targeting the PI3K pathway.Journal of translational medicine · 2024Review
- Endothelium-Mimetic Surface Modification Improves Antithrombogenicity and Enhances Patency of Vascular Grafts in Rats and Pigs.JACC. Basic to translational science · 2023Article
- Mechanisms of Foreign Body Giant Cell Formation in Response to Implantable Biomaterials.Polymers · 2023Review
- Article
- Identification of Gene Co-Expression Networks Associated with Consensus Molecular Subtype-1 of Colorectal Cancer.Cancers · 2021Article
- Review
- CCL28-induced CCR10/eNOS interaction in angiogenesis and skin wound healing.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- The Chemokine Receptor CCR7 Uses Distinct Signaling Modules With Biased Functionality to Regulate Dendritic Cells.Frontiers in immunology · 2020Review
- Potential use of compounds from sea cucumbers as MDM2 and CXCR4 inhibitors to control cancer cell growth.Experimental and therapeutic medicine · 2018Article
- Binding of Dickkopf-3 to CXCR7 Enhances Vascular Progenitor Cell Migration and Degradable Graft Regeneration.Circulation research · 2018Article
- Gγ identity dictates efficacy of Gβγ signaling and macrophage migration.The Journal of biological chemistry · 2018Article
- Cleaning up the environment in juvenile myelomonocytic leukemia.Translational cancer research · 2017Article
- The up-regulation of Myb may help mediate EGCG inhibition effect on mouse lung adenocarcinoma.Human genomics · 2016Article
- A Potential Contribution of Chemokine Network Dysfunction to the Depressive Disorders.Current neuropharmacology · 2016Review
- Chemokines and microRNAs in atherosclerosis.Cellular and molecular life sciences : CMLS · 2015Review
- Altered T-cell entry and egress in the absence of Coronin 1A attenuates murine acute graft versus host disease.European journal of immunology · 2014Article
- The emerging immunological role of post-translational modifications by reactive nitrogen species in cancer microenvironment.Frontiers in immunology · 2014Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of chemokines in mediating directional cell migration is well established, but more recently it has become evident that chemokines are able to couple to distinct signalling pathways that are involved in not only chemotaxis, but also cell growth and transcriptional activation. The signalling pathway controlled by the phosphoinositide 3-kinase (PI3K) family of lipid kinases has been the focus of much attention with respect to their role in chemokine-mediated functional responses. Indeed, there now exists convincing biochemical, pharmacological and genetic evidence that both CC and CXC chemokines stimulate PI3K-dependent chemotaxis of inflammatory cells such as eosinophils, macrophages, neutrophils and T lymphocytes. This review considers the role of individual PI3Ks (e.g. the p85/p110 heterodimer, PI3Kgamma and PI3KC2alpha) as well their downstream effector targets in mediating chemokine-stimulated cell migration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.