ArticleRNA (New York, N.Y.)2002
Influence of the stacking potential of the base 3' of tandem shift codons on -1 ribosomal frameshifting used for gene expression.
Article in RNA (New York, N.Y.), 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed.
- The energy landscape of -1 ribosomal frameshifting.Science advances · 2020Article
- Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use.Nucleic acids research · 2016Review
- The highly conserved codon following the slippery sequence supports -1 frameshift efficiency at the HIV-1 frameshift site.PloS one · 2015Article
- Dynamic pathways of -1 translational frameshifting.Nature · 2014Article
- Analysis of tetra- and hepta-nucleotides motifs promoting -1 ribosomal frameshifting in Escherichia coli.Nucleic acids research · 2014Article
- The interplay of mRNA stimulatory signals required for AUU-mediated initiation and programmed -1 ribosomal frameshifting in decoding of transposable element IS911.Journal of bacteriology · 2011Article
- Translational defects in a mutant deficient in YajL, the bacterial homolog of the parkinsonism-associated protein DJ-1.Journal of bacteriology · 2010Article
- Translational errors: from yeast to new therapeutic targets.FEMS yeast research · 2010Review
- Footprinting analysis of BWYV pseudoknot-ribosome complexes.RNA (New York, N.Y.) · 2009Article
- The stimulatory RNA of the Visna-Maedi retrovirus ribosomal frameshifting signal is an unusual pseudoknot with an interstem element.RNA (New York, N.Y.) · 2008Article
- Identification of novel ligands for the RNA pseudoknot that regulate -1 ribosomal frameshifting.Bioorganic & medicinal chemistry · 2008Article
- Codon-triplet context unveils unique features of the Candida albicans protein coding genome.BMC genomics · 2007Article
- Programmed ribosomal frameshifting in HIV-1 and the SARS-CoV.Virus research · 2006Review
- Identification of programmed translational -1 frameshifting sites in the genome of Saccharomyces cerevisiae.Genome research · 2005Article
- Article
- An extended signal involved in eukaryotic -1 frameshifting operates through modification of the E site tRNA.Molecular cell · 2005Article
- A reassessment of the response of the bacterial ribosome to the frameshift stimulatory signal of the human immunodeficiency virus type 1.RNA (New York, N.Y.) · 2004Article
- -1 frameshifting at a CGA AAG hexanucleotide site is required for transposition of insertion sequence IS1222.Journal of bacteriology · 2004Article
- P-site tRNA is a crucial initiator of ribosomal frameshifting.RNA (New York, N.Y.) · 2004Review
- Translational recoding signals between gag and pol in diverse LTR retrotransposons.RNA (New York, N.Y.) · 2003Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Translating ribosomes can shift reading frame at specific sites with high efficiency for gene expression purposes. The most common type of shift to the -1 frame involves a tandem realignment of two anticodons from pairing with mRNA sequence of the form X XXY YYZ to XXX YYY Z where the spaces indicate the reading frame. The predominant -1 shift site of this type in eubacteria is A AAA AAG. The present work shows that in Escherichia coli the identity of the 6 nt 3' of this sequence can be responsible for a 14-fold variation in frameshift frequency. The first 3' nucleotide has the primary effect, with, in order of decreasing efficiency, U > C > A > G. This effect is independent of other stimulators of frameshifting. It is detected with other X XXA AAG sequences, but not with several other heptameric -1 shift sites. Pairing of E. coli tRNALYS with AAG is especially weak at the third codon position. We propose that strong stacking of purines 3' of AAG stabilizes pairing of tRNALys, diminishing the chance of codon:anticodon dissociation that is a prerequisite for the realignment involved in frameshifting.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.