ArticleBritish journal of cancer2002
Dendritic cell density and activation status in human breast cancer -- CD1a, CMRF-44, CMRF-56 and CD-83 expression.
Article in British journal of cancer, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 74 citations in OpenAlex.
- The Application of Dendritic Cells Vaccines in Tumor Therapy and Their Combination with Biomimetic Nanoparticles.Vaccines · 2025Review
- Chemoradiotherapy and Lymph Node Metastasis Affect Dendritic Cell Infiltration and Maturation in Regional Lymph Nodes of Laryngeal Cancer.International journal of molecular sciences · 2024Article
- Breast Cancer Immunity: It is TIME for the Next Chapter.Cold Spring Harbor perspectives in medicine · 2024Review
- Cellular Heterogeneity of Activated Primary Human Macrophages and Associated Drug-Gene Networks: From Biology to Precision Therapeutics.Circulation · 2023Article
- Dendritic Cell Subpopulations Are Associated with Morphological Features of Breast Ductal Carcinoma In Situ.International journal of molecular sciences · 2023Article
- rPAC: Route based pathway analysis for cohorts of gene expression data sets.Methods (San Diego, Calif.) · 2022Article
- CD1a- and CD83-positive dendritic cells as prognostic markers of metastasis development in early breast cancer patients.Breast cancer (Tokyo, Japan) · 2021Article
- Conceptual Analogies Between Multi-Scale Feeding and Feedback Cycles in Supermassive Black Hole and Cancer Environments.Frontiers in oncology · 2021Review
- Regulation and characterization of tumor-infiltrating immune cells in breast cancer.International immunopharmacology · 2021Article
- São Paulo School of Advanced Sciences on Vaccines: an overview.The journal of venomous animals and toxins including tropical diseases · 2020Review
- Human Tumor-Infiltrating Dendritic Cells: From in Situ Visualization to High-Dimensional Analyses.Cancers · 2019Review
- Adaptive immunity programmes in breast cancer.Immunology · 2017Review
- The Differential Contribution of the Innate Immune System to a Good Pathological Response in the Breast and Axillary Lymph Nodes Induced by Neoadjuvant Chemotherapy in Women with Large and Locally Advanced Breast Cancers.Journal of immunology research · 2017Article
- Human breast cancer-derived soluble factors facilitate CCL19-induced chemotaxis of human dendritic cells.Scientific reports · 2016Article
- Immune profiling in human breast cancer using high-sensitivity detection and analysis techniques.JRSM open · 2015Article
- T Lymphocyte Inhibition by Tumor-Infiltrating Dendritic Cells Involves Ectonucleotidase CD39 but Not Arginase-1.BioMed research international · 2015Article
- Article
- Identification of dendritic cells, B cell and T cell subsets in Tasmanian devil lymphoid tissue; evidence for poor immune cell infiltration into devil facial tumors.Anatomical record (Hoboken, N.J. : 2007) · 2014Article
- Clinical evaluation of systemic and local immune responses in cancer: time for integration.Cancer immunology, immunotherapy : CII · 2014Article
- Macrophages and dendritic cells as actors in the immune reaction of classical Hodgkin lymphoma.PloS one · 2014Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Low CD1a-positive putative dendritic cell numbers in human breast cancer has recently been described and may explain the apparent 'poor immunogenicity' previously reported in breast cancer. Little attention has been given to dendritic cell activation within the tumour microenvironment, which is another reason why the in-situ immune response may be severely deficient. We have therefore examined CD1a expression as a marker for dendritic cells, together with CMRF-44 and -56 as markers of dendritic cell activation status, in 40 human breast cancers. The results demonstrate few or no CD1a-positive putative dendritic cells and minimal or no expression of the dendritic cell activation markers. Both dendritic cell number and dendritic cell activation appear substantially deficient in human breast cancers, regardless of tumour histological grade.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.