Trial reportBritish journal of cancer2002
A randomized trial of specialist genetic assessment: psychological impact on women at different levels of familial breast cancer risk.
Trial report in British journal of cancer, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 4 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Systematic evidence review and meta-analysis of outcomes associated with cancer genetic counseling.Genetics in medicine : official journal of the American College of Medical Genetics · 2024Pooled it
- Current Genetic Service Delivery Models for the Provision of Genetic Testing in Europe: A Systematic Review of the Literature.Frontiers in genetics · 2019Pooled it
- Cancer genetic risk assessment for individuals at risk of familial breast cancer.The Cochrane database of systematic reviews · 2012Pooled it
- How risk is perceived, constructed and interpreted by clients in clinical genetics, and the effects on decision making: systematic review.Journal of genetic counseling · 2008Pooled it
- Genetic testing for BRCA1: effects of a randomised study of knowledge provision on interest in testing and long term test uptake; implications for the NICE guidelines.Familial cancer · 2009Trial
- Knowledge and expectations of women undergoing cancer genetic risk assessment: a qualitative analysis of free-text questionnaire comments.Journal of genetic counseling · 2007Trial
- Health economics and genetic service development: a familial cancer genetic example.Familial cancer · 2004Trial
- A randomised controlled trial of breast cancer genetics services in South East Scotland: psychological impact.British journal of cancer · 2003Trial
- Reminders of cancer risk and pain catastrophizing: relationships with cancer worry and perceived risk in women with a first-degree relative with breast cancer.Familial cancer · 2019Article
- Cancer Worry, Perceived Risk and Cancer Screening in First-Degree Relatives of Patients with Familial Gastric Cancer.Journal of genetic counseling · 2016Article
- Linking genetic counseling content to short-term outcomes in individuals at elevated breast cancer risk.Journal of genetic counseling · 2014Article
- Implementation and outcomes of telephone disclosure of clinical BRCA1/2 test results.Patient education and counseling · 2013Article
- What counts as effective genetic counselling for presymptomatic testing in late-onset disorders? A study of the consultand's perspective.Journal of genetic counseling · 2013Article
- An online resource of digital stories about cancer genetics: qualitative study of patient preferences and information needs.Journal of medical Internet research · 2011Article
- Genetic risk, perceived risk, and cancer worry in daughters of breast cancer patients.Journal of genetic counseling · 2011Article
- Article
- [BRCA1- and BRCA2 mutations: Clinical management of patients with hereditary breast and ovarian cancer].Wiener medizinische Wochenschrift (1946) · 2010Review
- Dispositional cancer worry: convergent, divergent, and predictive validity of existing scales.Journal of psychosocial oncology · 2010Article
- Factors associated with intrusive cancer-related worries in women undergoing cancer genetic risk assessment.Familial cancer · 2009Article
- Mammographic screening for young women with a family history of breast cancer: knowledge and views of those at risk.British journal of cancer · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim was to compare the psychological impact of a multidisciplinary specialist genetics service with surgical provision in women at high risk and those at lower risk of familial breast cancer. Women (n=735) were randomized to a surgical consultation with (trial group) or without (control group) specialist genetic risk assessment and the possible offer of presymptomatic genetic testing. Participants completed questionnaires before and immediately after the consultation to assess anxiety, cancer worry, perceived risk, interest in genetic testing and satisfaction. Responses of subgroups of women stratified by clinicians as low, moderate, or high risk were analyzed. There were no significant main effects of study intervention on any outcome variable. Regardless of risk information, there was a statistically significant reduction in state anxiety (P<0.001). Reductions in cancer worry and perceived risk were significant for women at low or moderate risk (P<0.001) but not those at high risk, and satisfaction was significantly lower in the high risk group (P<0.001). In high risk women who received specialist genetic input, there was a marginally significant trend towards increased perceived risk. The effect of risk information on interest in genetic testing was not significant. Breast care specialists other than geneticists might provide assessments of breast cancer risk, reassuring women at reduced risk and targeting those at high risk for specialist genetic counselling and testing services. These findings are discussed in relation to the existing UK Calman-Hine model of service delivery in cancer genetics. DOI: 10.1038/sj/bjc/6600051 www.bjcancer.comCopyright 2002 The Cancer Research Campaign
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.