Evidence map›Paper›PMID 11869620›Full record

SynthesisThe Cochrane database of systematic reviews2002

Corticosteroids for chronic inflammatory demyelinating polyradiculoneuropathy.

M M Mehndiratta, R A Hughes

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in The Cochrane database of systematic reviews, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Immune-Mediated Neuropathies: Pathophysiology and Management.International journal of molecular sciences · 2023
    Review
  4. Review
  5. Article
  6. VIP-expressing dendritic cells protect against spontaneous autoimmune peripheral polyneuropathy.Molecular therapy : the journal of the American Society of Gene Therapy · 2014
    Article
  7. Review
  8. Therapeutic plasma exchange in neurology: 2012.Journal of clinical apheresis · 2013
    Review
  9. Article
  10. Article
  11. Review
  12. Treatment of chronic inflammatory demyelinating polyneuropathy.Current treatment options in neurology · 2010
    Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Treatment of dys-immune neuropathies.Journal of neurology · 2005
    Review
  19. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

M M MehndirattaNeurology, GB Pant Hospital, D-II / 103, Kidwai Nagar-West, New Delhi, India, 110023. mmehndi@ndf.vsnl.net.in
R A Hughes

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic inflammatory demyelinating polyradiculoneuropathy is a peripheral neuropathy caused by peripheral nerve inflammation probably due to autoimmunity and would be expected to benefit from corticosteroids. Non-randomised studies suggest that corticosteroids are often beneficial.

objectivesTo evaluate the efficacy of corticosteroids for treating chronic inflammatory demyelinating polyradiculoneuropathy. SEARCH STRATEGY: Search of the Cochrane Neuromuscular Disease Group register for randomised trials of corticosteroids treatment for chronic inflammatory demyelinating polyradiculoneuropathy and enquiry from subject experts. SELECTION CRITERIA: Types of studies: All randomised or quasi-randomised trials Types of Participants: All patients with chronic inflammatory demyelinating polyradiculoneuropathy who were diagnosed by an internationally accepted definition. Types of interventions: Treatment with any form of corticosteroids or adrenocorticotropic hormone. Types of outcome measures: PRIMARY OUTCOME MEASURE: Change in disability 12 weeks after randomisation. SECONDARY OUTCOME MEASURES: 1. Change in impairment 12 weeks after randomisation. 2. Change in maximum motor nerve conduction velocity or compound muscle action potential amplitude after 12 weeks. 3. Side effects of corticosteroids. DATA COLLECTION AND ANALYSIS: One author extracted the data and the other checked them. MAIN

resultsWe identified one randomised controlled trial, an open study in which 19 corticosteroids treated patients showed more improvement in impairment than 16 untreated controls after 12 weeks. Experience from large non-randomised studies suggests that steroids are beneficial. REVIEWER'S

conclusionsA single randomised controlled trial with 35 participants provided weak evidence to support the conclusion from non-randomised studies that oral corticosteroids reduce impairment in chronic inflammatory demyelinating polyradiculoneuropathy. Corticosteroids are known to have serious long term side effects. The long term risk and benefits have not been adequately studied.

Indexed as

Adrenal Cortex HormonesAnti-Inflammatory AgentsHumansPolyradiculoneuropathy, Chronic Inflammatory DemyelinatingPrednisoneAdrenal Cortex HormonesAnti-Inflammatory AgentsPrednisone

Identifiers

PMID11869620

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.