ReviewImmunologic research2002
Insights into the immunopathogenesis of multiple sclerosis.
Review in Immunologic research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- T cell vaccination benefits relapsing progressive multiple sclerosis patients: a randomized, double-blind clinical trial.PloS one · 2012Trial
- Leveraging Kinase Drugs for Neurosciences: Discovery of Selective, CNS-Penetrant Reversible Bruton's Tyrosine Kinase Inhibitors as Therapeutics for Neuroinflammation.Journal of medicinal chemistry · 2026Article
- The Quinazoline Derivative, QNZ, Alleviates Experimental Autoimmune Encephalomyelitis by Suppressing Th1 and Th17 Cells.CNS neuroscience & therapeutics · 2025Article
- Obesity Promotes EAE Through IL-6 and CCL-2-Mediated T Cells Infiltration.Frontiers in immunology · 2019Article
- Combination of interleukin-10 gene promoter polymorphisms with HLA-DRB1*15 allele is associated with multiple sclerosis.The Indian journal of medical research · 2017Article
- Review
- High fat diet exacerbates neuroinflammation in an animal model of multiple sclerosis by activation of the Renin Angiotensin system.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2014Article
- Antineuroinflammatory and neurotrophic effects of CNTF and C16 peptide in an acute experimental autoimmune encephalomyelitis rat model.Frontiers in neuroanatomy · 2013Article
- Dose-dependent anti-inflammatory and neuroprotective effects of an ανβ3 integrin-binding peptide.Mediators of inflammation · 2013Article
- Expression of scavenger receptor A on antigen presenting cells is important for CD4+ T-cells proliferation in EAE mouse model.Journal of neuroinflammation · 2012Article
- Article
- Myelin-phagocytosing macrophages modulate autoreactive T cell proliferation.Journal of neuroinflammation · 2011Article
- Augmentation of regulatory B cell activity in experimental allergic encephalomyelitis by glatiramer acetate.Journal of neuroimmunology · 2011Article
- Review
- Neuroprotection and neurogeneration in MS and its animal model EAE effected by glatiramer acetate.Journal of neural transmission (Vienna, Austria : 1996) · 2009Review
- T-cells expressing natural killer (NK) receptors are altered in multiple sclerosis and responses to alpha-galactosylceramide are impaired.Journal of the neurological sciences · 2008Article
- Inflammation and its role in neuroprotection, axonal regeneration and functional recovery after spinal cord injury.Experimental neurology · 2008Review
- Article
- Autologous T-cell vaccination for multiple sclerosis: a perspective on progress.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2008Review
- Neurogenesis and neuroprotection in the CNS--fundamental elements in the effect of Glatiramer acetate on treatment of autoimmune neurological disorders.Molecular neurobiology · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). Significant progress has been made in our understanding of the etiology of MS. MS is widely believed to be an autoimmune disease that results from aberrant immune responses to CNS antigens. T cells are considered to be crucial in orchestrating an immunopathological cascade that results in damage to the myelin sheath. This review summarizes the currently available data supporting the idea that myelin reactive T cells are actively involved in the immunopathogenesis of MS. Some of the therapeutic strategies for MS are discussed with a focus on immunotherapies that aim to specifically target the myelin reactive T cells.
Indexed as
Identifiers
11868933What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.