ArticleThorax2002
Additive anti-inflammatory effect of formoterol and budesonide on human lung fibroblasts.
Article in Thorax, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The trial behind it
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Who cites it
19 citing papers in PubMed.
- Fixed airflow obstruction in asthma: a descriptive study of patient profiles and effect on treatment responses.The Journal of asthma : official journal of the Association for the Care of Asthma · 2014Trial
- The effect of lung volume reduction surgery on chronic obstructive pulmonary disease exacerbations.American journal of respiratory and critical care medicine · 2008Trial
- A four-part guide to lung immunology: Invasion, inflammation, immunity, and intervention.Frontiers in immunology · 2023Review
- Clinical Relevance of the Anti-inflammatory Effects of Roflumilast on Human Bronchus: Potentiation by a Long-Acting Beta-2-Agonist.Frontiers in pharmacology · 2020Article
- Beclomethasone dipropionate and formoterol fumarate synergistically interact in hyperresponsive medium bronchi and small airways.Respiratory research · 2018Article
- Understanding how long-acting βBritish journal of pharmacology · 2016Review
- Anti-inflammatory effects of budesonide in human lung fibroblast are independent of histone deacetylase 2.Journal of inflammation research · 2013Article
- Roflumilast inhibits lipopolysaccharide-induced tumor necrosis factor-α and chemokine production by human lung parenchyma.PloS one · 2013Article
- Anti-inflammatory effects of β2 adrenergic receptor agonists in experimental acute lung injury.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012Article
- Combined Beta-agonists and corticosteroids do not inhibit extracellular matrix protein production in vitro.Journal of allergy · 2012Article
- The β2-subtype of adrenoceptors mediates inhibition of pro-fibrotic events in human lung fibroblasts.Naunyn-Schmiedeberg's archives of pharmacology · 2011Article
- Effects of β(2) Agonists, Corticosteroids, and Novel Therapies on Rhinovirus-Induced Cytokine Release and Rhinovirus Replication in Primary Airway Fibroblasts.Journal of allergy · 2011Article
- Budesonide/formoterol combination in COPD: a US perspective.International journal of chronic obstructive pulmonary disease · 2010Review
- Section 3. A discussion of flexible dosing and patient-centered therapy: highlights of the asthma summit 2009: beyond the guidelines.The World Allergy Organization journal · 2010Article
- A Holy Grail of asthma management: toward understanding how long-acting beta(2)-adrenoceptor agonists enhance the clinical efficacy of inhaled corticosteroids.British journal of pharmacology · 2008Review
- The effect of aerosolized and intravenously administered clenbuterol and aerosolized fluticasone propionate on horses challenged with Aspergillus fumigatus antigen.Veterinary research communications · 2006Article
- New treatment regimes for virus-induced exacerbations of asthma.Pulmonary pharmacology & therapeutics · 2006Review
- Benefit-risk assessment of long-acting beta2-agonists in asthma.Drug safety · 2004Review
- Pharmacotherapy and airway remodelling in asthma?Thorax · 2003Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt has been shown that treatment with a long acting beta2 agonist in addition to a glucocorticoid is beneficial in the treatment of asthma. In asthma inflammatory cells, particularly eosinophils, migrate into the pulmonary tissue and airway lumen by means of adhesion molecules expressed on resident tissue cells--that is, fibroblasts--and become activated by cytokines and adhesive interactions. A study was undertaken to determine whether an interaction exists between the long acting beta2 agonist formoterol and the glucocorticoid budesonide on inhibition of adhesion molecule expression, as well as chemo/cytokine production by human lung fibroblasts.
methodsLung fibroblasts were preincubated with therapeutically relevant drug concentrations of 10(-8) M to 10(-10) M. Cells were stimulated with interleukin (IL)-1beta (1 or 10 U/ml) for 8 hours and supernatants were collected for measurement of GM-CSF and IL-8 concentrations. The cells were fixed and subjected to a cell surface ELISA technique to measure the expression of ICAM-1 and VCAM-1.
resultsFormoterol exerted an additive effect on the inhibition of IL-1beta stimulated ICAM-1 and VCAM-1 upregulation and GM-CSF production by budesonide in concentrations of 10(-9) M and above (p<0.05). IL-8 production was not influenced by formoterol.
conclusionFormoterol exerts an additive effect on the anti-inflammatory properties of budesonide. In vitro data support the finding that the combination of budesonide and formoterol in asthma treatment strengthens the beneficial effect of either drug alone.
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Registered trials
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