Trial reportThorax2002
Influence of cigarette smoking on inhaled corticosteroid treatment in mild asthma.
Trial report in Thorax, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 126 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized, Double Blind, Placebo-controlled Three-way Crossover Study in Mild Asthmatics to Evaluate the Effect of Smoking Status on the Attenuation by Inhaled Corticosteroids of the Allergen-induced Asthmatic Response.
Small Airways Involvement in Smoker Asthmatic Patients: a Pilot Study
Interrelation Between Bronchial Asthma and Smoking
Therapeutic Drug Monitoring of Corticosteroids/β2-agonists in Hair in Asthmatic Patients: an Open-label Feasibility Study
Who cites it
126 citing papers in PubMed, 2 syntheses or guidelines pooled it, 547 citations in OpenAlex.
- Addition of long-acting beta2-agonists to inhaled steroids versus higher dose inhaled steroids in adults and children with persistent asthma.The Cochrane database of systematic reviews · 2010Pooled it
- Triple therapy for COPD: a crude analysis from a systematic review of the evidence.Therapeutic advances in respiratory diseasePooled it
- Effect of smoking status on lung function, patient-reported outcomes, and safety among COPD patients treated with glycopyrrolate inhalation powder: pooled analysis of GEM1 and GEM2 studies.Respiratory research · 2019Trial
- Comparison of the efficacy of ciclesonide with that of budesonide in mild to moderate asthma patients after step-down therapy: a randomised parallel-group study.NPJ primary care respiratory medicine · 2014Trial
- Steroid resistance in COPD? Overlap and differential anti-inflammatory effects in smokers and ex-smokers.PloS one · 2014Trial
- Effects of short-term treatment with atorvastatin in smokers with asthma--a randomized controlled trial.BMC pulmonary medicine · 2011Trial
- Randomized controlled trial to improve care for urban children with asthma: results of the School-Based Asthma Therapy trial.Archives of pediatrics & adolescent medicine · 2011Trial
- Improving care for urban children with asthma: design and methods of the School-Based Asthma Therapy (SBAT) trial.The Journal of asthma : official journal of the Association for the Care of Asthma · 2008Trial
- Smoking affects response to inhaled corticosteroids or leukotriene receptor antagonists in asthma.American journal of respiratory and critical care medicine · 2007Trial
- Efficacy of low and high dose inhaled corticosteroid in smokers versus non-smokers with mild asthma.Thorax · 2005Trial
- Effects of a short course of inhaled corticosteroids in noneosinophilic asthmatic subjects.Canadian respiratory journalTrial
- Misconceptions of Traits to Predict Response to Inhaled Corticosteroid and Bronchodilator Therapies in Asthma: A Narrative Review.Pulmonary therapy · 2026Review
- Smoking and Lung Function Response to Inhaled Glucocorticoids in Adult-Onset Asthma.Journal of asthma and allergy · 2026Article
- Non-type 2 airway inflammation in severe asthma: from bench to bedside.Frontiers in immunology · 2026Review
- Real-life impact of anti-IL5 therapy on exacerbation types in patients with obstructive lung disease.BMJ open respiratory research · 2025Article
- Tobacco and asthma: presenting the world health organization (WHO) tobacco knowledge summary.Substance abuse treatment, prevention, and policy · 2025Review
- Why Every Asthma Patient Tells a Different Story.Journal of clinical medicine · 2025Article
- Naturally derived bioactive compounds as regulators of oxidative stress and inflammation in asthma.Chinese medicine · 2025Review
- The Effect of Environmental Factors, Health Behaviors, and Psychosocial Aspects on Allergic Diseases in Korean Adolescents.Medicina (Kaunas, Lithuania) · 2025Article
- Genetic inhibition of nicotinamide N-methyltransferase and prevention of alcohol-associated fatty liver in humans.Journal of human genetics · 2025Article
66 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough inhaled corticosteroids have an established role in the treatment of asthma, studies have tended to concentrate on non-smokers and little is known about the possible effect of cigarette smoking on the efficacy of treatment with inhaled steroids in asthma. A study was undertaken to investigate the effect of active cigarette smoking on responses to treatment with inhaled corticosteroids in patients with mild asthma.
methodsThe effect of treatment with inhaled fluticasone propionate (1000 microg daily) or placebo for 3 weeks was studied in a double blind, prospective, randomised, placebo controlled study of 38 steroid naïve adult asthmatic patients (21 non-smokers). Efficacy was assessed using morning and evening peak expiratory flow (PEF) readings, spirometric parameters, bronchial hyperreactivity, and sputum eosinophil counts. Comparison was made between responses to treatment in non-smoking and smoking asthmatic patients.
resultsThere was a significantly greater increase in mean morning PEF in non-smokers than in smokers following inhaled fluticasone (27 l/min v -5 l/min). Non-smokers had a statistically significant increase in mean morning PEF (27 l/min), mean forced expiratory volume in 1 second (0.17 l), and geometric mean PC20 (2.6 doubling doses), and a significant decrease in the proportion of sputum eosinophils (-1.75%) after fluticasone compared with placebo. No significant changes were observed in the smoking asthmatic patients for any of these parameters.
conclusionsActive cigarette smoking impairs the efficacy of short term inhaled corticosteroid treatment in mild asthma. This finding has important implications for the management of patients with mild asthma who smoke.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.