ArticleProceedings of the National Academy of Sciences of the United States of America2002
Identification of a germ-line pro-B cell subset that distinguishes the fetal/neonatal from the adult B cell development pathway.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 29 citations in OpenAlex.
- Cluster-independent multiscale marker identification in single-cell RNA-seq data using localized marker detector (LMD).Communications biology · 2025Article
- Beneficial effects of IL-4 and IL-6 on rat neonatal target cardiac cells.Scientific reports · 2020Article
- MHC class II cell-autonomously regulates self-renewal and differentiation of normal and malignant B cells.Blood · 2019Article
- A neonatal blueprint for cardiac regeneration.Stem cell research · 2014Review
- Macrophages are required for neonatal heart regeneration.The Journal of clinical investigation · 2014Article
- Distinct B-cell lineage commitment distinguishes adult bone marrow hematopoietic stem cells.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Phenotypically distinct B cell development pathways map to the three B cell lineages in the mouse.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Developmental separation of V(D)J recombinase expression and initiation of IgH recombination in B lineage progenitors in vivo.The Journal of experimental medicine · 2004Article
- Extrathymic T cell lymphopoiesis: ontogeny and contribution to gut intraepithelial lymphocytes in athymic and euthymic mice.The Journal of experimental medicine · 2003Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Studies presented here show that the expression of CD4, MHC class II (Ia,) and B220 cleanly resolves a major and a minor subset within the earliest pro-B cell population (germ-line pro-B) in adult bone marrow (BM). The major subset expresses intermediate B220 and low CD4 levels. The minor subset, which constitutes roughly 20% of the adult germ-line pro-B, expresses very low B220 levels and does not express CD4. Ia is clearly detectable at low levels on the major germ-line pro-B subset, both in wild-type adult mice and in gene-targeted mice (RAG2-/- and microMT), in which B cell development terminates before the pre-B cell stage. A small proportion of cells in the more mature pro-B cell subsets (Hardy Fractions B and C) also express Ia at this level. In contrast, Ia levels on the minor subset are barely above (or equal to) background. Surprisingly, the major germ-line pro-B cell subset found in adults is missing in fetal and neonatal animals. All of the germ-line pro-B in these immature animals express a phenotype (very low B220, no CD4, or Ia) similar to that of the minor pro-B cell subset in adult BM. Because B cell development in fetal/neonatal animals principally results in B-1 cells, these findings demonstrate that the B-1 development pathway does not include the major germ-line pro-B subset found in adult BM and hence identify a very early difference between the B-1 and -2 development pathways.
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