ArticleProceedings of the National Academy of Sciences of the United States of America2002
Cybr, a cytokine-inducible protein that binds cytohesin-1 and regulates its activity.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- Genetic and Inflammatory Signatures Associated With Worse Prognosis in Hospitalized Patients With Severe SARS-CoV-2 Infection With and Without Diabetes.Journal of medical virology · 2025Article
- Physiological and Pathological Roles of the Cytohesin Family in Neurons.International journal of molecular sciences · 2022Review
- Proteomic analysis in primary T cells reveals IL-7 alters T cell receptor thresholding via CYTIP/cytohesin/LFA-1 localisation and activation.The Biochemical journal · 2022Article
- Genome-wide DNA methylation associations with spontaneous preterm birth in US blacks: findings in maternal and cord blood samples.Epigenetics · 2018Article
- Human Cytomegalovirus-Induced Degradation of CYTIP Modulates Dendritic Cell Adhesion and Migration.Frontiers in immunology · 2017Article
- Arf6 guanine nucleotide exchange factor cytohesin-2 binds to CCDC120 and is transported along neurites to mediate neurite growth.The Journal of biological chemistry · 2014Article
- In human monocyte derived dendritic cells SOCS1 interacting with CYTIP induces the degradation of CYTIP by the proteasome.PloS one · 2013Article
- Cytip regulates dendritic-cell function in contact hypersensitivity.European journal of immunology · 2012Article
- Cytohesin-2/ARNO, through its interaction with focal adhesion adaptor protein paxillin, regulates preadipocyte migration via the downstream activation of Arf6.The Journal of biological chemistry · 2010Article
- The CNK1 scaffold binds cytohesins and promotes insulin pathway signaling.Genes & development · 2010Article
- GRASP and IPCEF promote ARF-to-Rac signaling and cell migration by coordinating the association of ARNO/cytohesin 2 with Dock180.Molecular biology of the cell · 2010Article
- Transcriptional profiling reveals developmental relationship and distinct biological functions of CD16+ and CD16- monocyte subsets.BMC genomics · 2009Article
- Gene duplication in early vertebrates results in tissue-specific subfunctionalized adaptor proteins: CASP and GRASP.Journal of molecular evolution · 2008Article
- The N-terminal coiled-coil domain of the cytohesin/ARNO family of guanine nucleotide exchange factors interacts with Galphaq.Molecular and cellular biochemistry · 2007Article
- Cytohesin binder and regulator (cybr) is not essential for T- and dendritic-cell activation and differentiation.Molecular and cellular biology · 2006Article
- The scaffold protein Cybr is required for cytokine-modulated trafficking of leukocytes in vivo.Molecular and cellular biology · 2006Article
- Rapid chemokinetic movement and the invasive potential of lung cancer cells; a functional molecular study.BMC cancer · 2006Article
- Structural determinants of phosphoinositide selectivity in splice variants of Grp1 family PH domains.The EMBO journal · 2004Article
- Identification of genes differentially expressed in T cells following stimulation with the chemokines CXCL12 and CXCL10.BMC immunology · 2004Article
- Phylogenetic analysis of Sec7-domain-containing Arf nucleotide exchangers.Molecular biology of the cell · 2004Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
Cytokines regulate lymphocyte development and differentiation, but precisely how they control these processes is still poorly understood. By using microarray technology to detect cytokine-induced genes, we identified a cDNA encoding Cybr, which was increased markedly in cells incubated with IL-2 and IL-12. The mRNA was most abundant in hematopoietic cells and tissues. The predicted amino acid sequence is similar to that of GRP-1-associated protein (GRASP), a recently identified retinoic acid-induced cytohesin-binding protein. Physical interaction, dependent on the coiled-coil domains of Cybr and cytohesin-1, was demonstrated by coimmunoprecipitation of the overexpressed proteins from 293T cells. Cytohesin-1, in addition to its role in cell adhesion, is a guanine nucleotide-exchange protein activator of ARF GTPases. Acceleration of guanosine 5prime prime or minute-O-(thiotriphosphate) binding to ARF by cytohesin-1 in vitro was enhanced by Cybr. Because the binding protein modified activation of ADP ribosylation factor by cytohesin-1, we designate this cytokine-inducible protein Cybr (cytohesin binder and regulator).
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