ArticleProceedings of the National Academy of Sciences of the United States of America2002
Genetic instability favoring transversions associated with ErbB2-induced mammary tumorigenesis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Genomic variation between PRSV resistant transgenic SunUp and its progenitor cultivar Sunset.BMC genomics · 2020Article
- DMBA promotes ErbB2‑mediated carcinogenesis via ErbB2 and estrogen receptor pathway activation and genomic instability.Oncology reports · 2018Article
- Discriminating somatic and germline mutations in tumor DNA samples without matching normals.Genome research · 2015Article
- A comparative analysis of algorithms for somatic SNV detection in cancer.Bioinformatics (Oxford, England) · 2013Article
- Intraductally administered pegylated liposomal doxorubicin reduces mammary stem cell function in the mammary gland but in the long term, induces malignant tumors.Breast cancer research and treatment · 2012Article
- Cytogenetic analysis of a malignant triton tumour by comparative genomic hybridization (CGH) and review of the literature.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2011Review
- Molecular mechanisms associated with leukemic transformation of MPL-mutant myeloproliferative neoplasms.Haematologica · 2010Article
- The mutational spectrum of non-CpG DNA varies with CpG content.Genome research · 2010Article
- Modeling variation in tumors in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Phospholipase C delta-4 overexpression upregulates ErbB1/2 expression, Erk signaling pathway, and proliferation in MCF-7 cells.Molecular cancer · 2004Article
- A new mutator phenotype in breast cancer?Proceedings of the National Academy of Sciences of the United States of America · 2002Article
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10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been argued that genetic instability is required to generate the myriad mutations that fuel tumor initiation and progression and, in fact, patients with heritable cancer susceptibility syndromes harbor defects in specific genes that normally maintain DNA integrity. However, the vast majority of human cancers arise sporadically, in the absence of deficiencies in known "mutator" genes. We used a cII-based mutation detection assay to show that the mean frequency of forward mutations in primary mammary adenocarcinomas arising in mouse mammary tumor virus-c-erbB2 transgenic mice harboring multiple copies of the lambda bacteriophage genome was significantly higher than in aged-matched, wild-type mammary tissue. Analysis of the cII mutational spectrum within the mammary tumor genomic DNA demonstrated a >6-fold elevation in transversion mutation frequency, resulting in a highly unusual inversion of the transition/transversion ratio characteristic of normal epithelium; frameshift mutation frequencies were unaltered. Arising oncogenic point mutations within the c-erbB2 transgene of such tumors were predominantly transversions as well. Data from this model system support the notion that elaboration of a mutator phenotype is a consequential event in breast cancer and suggest that a novel DNA replication/repair gene is a relatively early mutational target in c-erbB2-induced mammary tumorigenesis.
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