ArticleProceedings of the National Academy of Sciences of the United States of America2002
Invariant chain induces B cell maturation in a process that is independent of its chaperonic activity.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 76 citations in OpenAlex.
- Review
- Autophagy Differentially Influences Toll-like Receptor 9 and B Cell-Receptor-Mediated B Cell Expansion, Expression of Major Histocompatibility Class II Proteins, and Antigenic Peptide Presentation.International journal of molecular sciences · 2025Article
- Exosomes derived from microRNA-540-3p overexpressing mesenchymal stem cells promote immune toleranceWorld journal of stem cells · 2024Article
- CD74 is expressed in a subset of pediatric acute myeloid leukemia patients and is a promising target for therapy: a report from the Children's Oncology Group.Haematologica · 2024Article
- The role of CD74 in cardiovascular disease.Frontiers in cardiovascular medicine · 2022Review
- CD74 is a regulator of hematopoietic stem cell maintenance.PLoS biology · 2021Article
- Evolution of male pregnancy associated with remodeling of canonical vertebrate immunity in seahorses and pipefishes.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Knockdown of CD-74 in the Proliferative and Apoptotic Activity of Breast Cancer Cells.Open access Macedonian journal of medical sciences · 2019Article
- The macrophage migration inhibitory factor pathway in human B cells is tightly controlled and dysregulated in multiple sclerosis.European journal of immunology · 2018Article
- Measurements of heterotypic associations between cluster of differentiation CD74 and CD44 in human breast cancer-derived cells.Oncotarget · 2017Article
- CD74 Deficiency Mitigates Systemic Lupus Erythematosus-like Autoimmunity and Pathological Findings in Mice.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- The biological function and significance of CD74 in immune diseases.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2017Review
- Review
- The Other Function: Class II-Restricted Antigen Presentation by B Cells.Frontiers in immunology · 2017Review
- CD74 interferes with the expression of fas receptor on the surface of lymphoma cells.Journal of experimental & clinical cancer research : CR · 2014Article
- Transgene expression in various organs post BM-HSC transplantation.Stem cell research · 2014Article
- B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8- dendritic cells require the intramembrane endopeptidase SPPL2A.The Journal of experimental medicine · 2013Article
- The intramembrane protease Sppl2a is required for B cell and DC development and survival via cleavage of the invariant chain.The Journal of experimental medicine · 2013Article
- The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain.The Journal of experimental medicine · 2013Article
- Shark class II invariant chain reveals ancient conserved relationships with cathepsins and MHC class II.Developmental and comparative immunology · 2012Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early stages of B cell development take place in the bone marrow, resulting in formation of immature B cells, which migrate to the spleen for their final differentiation into mature cells. This final maturation step is essential for B cells to become responsive to antigens and to participate in the immune response. Previously, we showed that the MHC class II chaperone, invariant chain (Ii), controls the differentiation of B cells from the immature to the mature stage. In this study, by generating transgenic mice expressing truncated Ii lacking its luminal domain, we could dissect the chaperonin activity of Ii from its role in B cell maturation. We demonstrate in vivo that Ii N-terminal domain is directly involved in the maturation of B cells and is sufficient to promote B cell differentiation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.