ArticleProceedings of the National Academy of Sciences of the United States of America2002
Analysis of the ultraviolet B response in primary human keratinocytes using oligonucleotide microarrays.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
62 citing papers in PubMed, 192 citations in OpenAlex.
- Characterization of a human skin equivalent model to study the effects of ultraviolet B radiation on keratinocytes.Tissue engineering. Part C, Methods · 2014Trial
- In vivo identification of solar radiation-responsive gene network: role of the p38 stress-dependent kinase.PloS one · 2010Trial
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- The Modulatory Influence of Plant-Derived Compounds on Human Keratinocyte Function.International journal of molecular sciences · 2021Review
- Investigations into Chemical Components fromJournal of fungi (Basel, Switzerland) · 2021Article
- Counteracting the Ramifications of UVB Irradiation and Photoaging withMolecules (Basel, Switzerland) · 2021Article
- Radiofrequency Irradiation Attenuates High-Mobility Group Box 1 and Toll-like Receptor Activation in Ultraviolet B-Induced Skin Inflammation.Molecules (Basel, Switzerland) · 2021Article
- Desmosomes as Signaling Hubs in the Regulation of Cell Behavior.Frontiers in cell and developmental biology · 2021Review
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- UVB-dependent inhibition of lipin-1 protects against proinflammatory responses in human keratinocytes.Experimental & molecular medicine · 2020Article
- Phenotypic Plasticity of Fibroblasts during Mammary Carcinoma Development.International journal of molecular sciences · 2019Article
- Skin Microbiome Modulates the Effect of Ultraviolet Radiation on Cellular Response and Immune Function.iScience · 2019Article
- Circadian Expression of TIMP3 Is Disrupted by UVB Irradiation and Recovered by Green Tea Extracts.International journal of molecular sciences · 2019Article
- Unexpected dose response of HaCaT to UVB irradiation.In vitro cellular & developmental biology. Animal · 2018Article
- The application of transcriptional benchmark dose modeling for deriving thresholds of effects associated with solar-simulated ultraviolet radiation exposure.Environmental and molecular mutagenesis · 2018Article
- TIMP3 is a CLOCK-dependent diurnal gene that inhibits the expression of UVB-induced inflammatory cytokines in human keratinocytes.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
- Coordinated activation of a cluster of MMP genes in response to UVB radiation.Scientific reports · 2018Article
- Melanocyte Stem Cell Activation and Translocation Initiate Cutaneous Melanoma in Response to UV Exposure.Cell stem cell · 2017Article
- Transcription factors and stress response gene alterations in human keratinocytes following Solar Simulated Ultra Violet Radiation.Scientific reports · 2017Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
UV radiation is the most important environmental skin aggressor, causing cancer and other problems. This paper reports the use of oligonucleotide microarray technology to determine changes in gene expression in human keratinocytes after UVB treatment. Examination of the effects of different doses at different times after irradiation gave a global picture of the keratinocyte response to this type of insult. Five hundred thirty-nine regulated transcripts were found and organized into nine different clusters depending on behavior patterns. Classification of these genes into 23 functional categories revealed that several biological processes are globally affected by UVB. In addition to confirming a majority up-regulation of the transcripts related to the UV-specific inflammatory and stress responses, significant increases were seen in the expression of genes involved in basal transcription, splicing, and translation as well as in the proteasome-mediated degradation category. On the other hand, those transcripts belonging to the metabolism and adhesion categories were strongly downregulated. These results demonstrate the complexity of the transcriptional profile of the UVB response, describe several cellular processes previously not known to be affected by UV irradiation, and serve as a basis for the global characterization of UV-regulated genes and pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.