ArticleProceedings of the National Academy of Sciences of the United States of America2002
Thyroid hormone is a critical determinant for the regulation of the cochlear motor protein prestin.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 113 citations in OpenAlex.
- Postmarketing pharmacovigilance study of levothyroxine based on FDA adverse event reporting system (FAERS) and Mendelian randomization.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Causal linkage of Graves' disease with aging: Mendelian randomization analysis of telomere length and age-related phenotypes.BMC geriatrics · 2024Article
- Congenital Hypothyroidism and the Deleterious Effects on Auditory Function and Language Skills: A Narrative Review.Frontiers in endocrinology · 2021Review
- Recent advances in cochlear hair cell nanophysiology: subcellular compartmentalization of electrical signaling in compact sensory cells.Faculty reviews · 2020Review
- Developmental and Functional Hair Cell-Like Cells Induced by Atoh1 Overexpression in the Adult Mammalian CochleaNeural plasticity · 2020Article
- Guanylyl Cyclase A/cGMP Signaling Slows Hidden, Age- and Acoustic Trauma-Induced Hearing Loss.Frontiers in aging neuroscience · 2020Article
- The effect of AP-2δ on transcription of the Prestin gene in HEI-OC1 cells upon oxidative stress.Cellular & molecular biology letters · 2019Article
- Gαi Proteins are Indispensable for Hearing.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2018Article
- GC-B Deficient Mice With Axon Bifurcation Loss Exhibit Compromised Auditory Processing.Frontiers in neural circuits · 2018Article
- Prestin Contributes to Membrane Compartmentalization and Is Required for Normal Innervation of Outer Hair Cells.Frontiers in cellular neuroscience · 2018Article
- Specific Influences of Early Acoustic Environments on Cochlear Hair Cells in Postnatal Mice.Neural plasticity · 2018Article
- Pseudo-immortalization of postnatal cochlear progenitor cells yields a scalable cell line capable of transcriptionally regulating mature hair cell genes.Scientific reports · 2015Article
- Activity-dependent regulation of prestin expression in mouse outer hair cells.Journal of neurophysiology · 2015Article
- OSBPL2 encodes a protein of inner and outer hair cell stereocilia and is mutated in autosomal dominant hearing loss (DFNA67).Orphanet journal of rare diseases · 2015Article
- The role of thyroid and parathyroid metabolism disorders in the etiology of sudden onset dizziness.Medical science monitor : international medical journal of experimental and clinical research · 2014Article
- Hearing impairment in hypothyroid dwarf mice caused by mutations of the thyroid peroxidase gene.Journal of the Association for Research in Otolaryngology : JARO · 2014Article
- Generation of somatic electromechanical force by outer hair cells may be influenced by prestin-CASK interaction at the basal junction with the Deiter's cell.Histochemistry and cell biology · 2013Article
- Prestin regulation and function in residual outer hair cells after noise-induced hearing loss.PloS one · 2013Article
- Genetic background of Prop1(df) mutants provides remarkable protection against hypothyroidism-induced hearing impairment.Journal of the Association for Research in Otolaryngology : JARO · 2012Article
- Expression analysis of prestin and selected transcription factors in newborn rats.Cellular and molecular neurobiology · 2011Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The most impressive property of outer hair cells (OHCs) is their ability to change their length at high acoustic frequencies, thus providing the exquisite sensitivity and frequency-resolving capacity of the mammalian hearing organ. Prestin, a protein related to a sulfate/anion transport protein, recently has been identified and proposed as the OHC motor molecule. Homology searches of 1.5 kb of genomic DNA 5' of the coding region of the prestin gene allowed the identification of a thyroid hormone (TH) response element (TRE) in the first intron upstream of the prestin ATG codon. Prestin(TRE) bound TH receptors as a monomer or presumptive heterodimer and mediated a triiodothyronine-dependent transactivation of a heterologous promotor in response to triiodothyronine receptors alpha and beta. Retinoid X receptor-alpha had an additive effect. Expression of prestin mRNA and prestin protein was reduced strongly in the absence of TH. Although prestin protein typically was redistributed to the lateral membrane before the onset of hearing, an immature pattern of prestin protein distribution across the entire OHC membrane was noted in hypothyroid rats. The data suggest TH as a first transcriptional regulator of the motor protein prestin and as a direct or indirect modulator of subcellular prestin distribution.
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