ArticleProceedings of the National Academy of Sciences of the United States of America2002
Dynamics of bacterial phenotype selection in a colonized host.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Outcomes of multifarious selection on the evolution of visual signals.Proceedings. Biological sciences · 2023Article
- Evolutionary Virology at 40.Genetics · 2018Review
- Pan-genomic analyses identify keyGut · 2018Article
- Local genes for local bacteria: Evidence of allopatry in the genomes of transatlantic Campylobacter populations.Molecular ecology · 2017Article
- Chromosome painting in silico in a bacterial species reveals fine population structure.Molecular biology and evolution · 2013Article
- Host-dependent Lewis (Le) antigen expression in Helicobacter pylori cells recovered from Leb-transgenic mice.The Journal of experimental medicine · 2009Article
- Article
- Damage segregation at fissioning may increase growth rates: a superprocess model.Theoretical population biology · 2007Article
- Early-life family structure and microbially induced cancer risk.PLoS medicine · 2007Article
- UvrD helicase suppresses recombination and DNA damage-induced deletions.Journal of bacteriology · 2006Article
- Host Lewis phenotype-dependent Helicobacter pylori Lewis antigen expression in rhesus monkeys.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2006Article
- Chronic Helicobacter pylori infection with Sydney strain 1 and a newly identified mouse-adapted strain (Sydney strain 2000) in C57BL/6 and BALB/c mice.Infection and immunity · 2004Article
- Article
- Extensive repetitive DNA facilitates prokaryotic genome plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Plasticity of repetitive DNA sequences within a bacterial (Type IV) secretion system component.The Journal of experimental medicine · 2003Article
- Helicobacter pylori babA2, cagA, and s1 vacA genes work synergistically in causing intestinal metaplasia.Journal of clinical pathology · 2003Article
- The impact of parietal cells on Helicobacter pylori tropism and host pathology: an analysis using gnotobiotic normal and transgenic mice.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Helicobacter pylori does not require Lewis X or Lewis Y expression to colonize C3H/HeJ mice.Infection and immunity · 2002Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The population dynamics of Helicobacter pylori during colonization in an infected animal host provide a quantifiable experimental model of in vivo microbial phenotype evolution. Phenotype variability in H. pylori populations can be typed as polymorphic expression of Lewis antigens on their cell surfaces. The high mutational frequency of H. pylori for Lewis expression provides substrate for differential selection by the host. Experimental challenge and successful colonization of mice and gerbils allows tracking of H. pylori phenotype variability from the initial inoculation to the ultimate establishment of a quasispecies. Colonization data provide a quantitative experimental model of phenotype evolution in a relatively large population (>10(4) individuals) over a relatively long evolutionary time scale (>10(3) generations). A mathematical model is developed to interpret the data in terms of the dynamic processes occurring during colonization. The mathematical model distinguishes the roles of selection and mutation; quantifies the effects of initial phenotype diversity, mutational frequency, and selective advantage; and applies generally to phenotype evolution in biological populations.
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