ArticleProceedings of the National Academy of Sciences of the United States of America2002
Cytotoxic T lymphocyte antigen-4 (CTLA-4) limits the expansion of encephalitogenic T cells in experimental autoimmune encephalomyelitis (EAE)-resistant BALB/c mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 78 citations in OpenAlex.
- OCA-B promotes pathogenic maturation of stem-like CD4+ T cells and autoimmune demyelination.The Journal of clinical investigation · 2025Article
- Clinical drug screening reveals clofazimine potentiates the efficacy while reducing the toxicity of anti-PD-1 and CTLA-4 immunotherapy.Cancer cell · 2024Article
- Article
- Immune-related adverse events of immune checkpoint inhibitors: a review.Frontiers in immunology · 2023Review
- Antigen receptor-engineered Tregs inhibit CNS autoimmunity in cell therapy using nonredundant immune mechanisms in mice.European journal of immunology · 2022Article
- Review
- Interleukin-6 blockade abrogates immunotherapy toxicity and promotes tumor immunity.Cancer cell · 2022Article
- Natural killer cells as participants in pathogenesis of rat experimental autoimmune encephalomyelitis (EAE): lessons from research on rats with distinct age and strain.Central-European journal of immunology · 2019Article
- Strain-Related Differences in the Immune Response: Relevance to Human Stroke.Translational stroke research · 2016Review
- Pathways and gene networks mediating the regulatory effects of cannabidiol, a nonpsychoactive cannabinoid, in autoimmune T cells.Journal of neuroinflammation · 2016Article
- Co-stimulatory and Co-inhibitory Pathways in Autoimmunity.Immunity · 2016Review
- SOCS3 deletion in T lymphocytes suppresses development of chronic ocular inflammation via upregulation of CTLA-4 and expansion of regulatory T cells.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Using EAE to better understand principles of immune function and autoimmune pathology.Journal of autoimmunity · 2013Review
- Impaired function of CTLA-4 in the lungs of patients with chronic beryllium disease contributes to persistent inflammation.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Immune privilege as an intrinsic CNS property: astrocytes protect the CNS against T-cell-mediated neuroinflammation.Mediators of inflammation · 2013Review
- Strategies for optimizing the clinical impact of immunotherapeutic agents such as sipuleucel-T in prostate cancer.Journal of the National Comprehensive Cancer Network : JNCCN · 2012Article
- [Nervous system side effects of disease modifying treatments of rheumatoid arthritis].Zeitschrift fur Rheumatologie · 2012Article
- Immunoregulatory molecules are master regulators of inflammation during the immune response.FEBS letters · 2012Review
- Lessons learned from studies of natural resistance in murine experimental autoimmune encephalomyelitis.Current trends in immunology · 2012Article
- The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses.Nature reviews. Immunology · 2011Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
We and others previously reported that cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates the severity of peptide-induced experimental autoimmune encephalomyelitis (EAE) in mouse strains that are inherently susceptible to the disease. In this report, we show that CTLA-4 engagement also controls disease susceptibility in BALB/c mice, a strain considered to be resistant to EAE induction. Although immunization of BALB/c mice with syngeneic spinal cord homogenate or an I-A(d)-binding myelin peptide antigen failed to result in EAE, immunization with either antigen preparation in conjunction with anti-CTLA-4 resulted in both clinical and histological EAE. CTLA-4 blockade also resulted in a preferential increase in the frequency of antigen-specific T cells secreting IFN-gamma. We conclude that CTLA-4 controls susceptibility in BALB/c mice by limiting the expansion of autoreactive T cells present in the periphery, suggesting a mechanism whereby CTLA-4 contributes to the maintenance of peripheral T cell tolerance to self antigens.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.